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Evaluation of Efficacy and Safety of Specific Immunotherapy With Modified Allergen Extracts of House Dust Mites

2014-07-24 14:10:56 | BioPortfolio

Summary

The objective of this study is to evaluate the efficacy and safety of specific subcutaneous immunotherapy with modified allergen extracts.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment

Conditions

Allergic Rhinitis

Intervention

modified allergen extract of house dust mites, placebo

Location

Madrid
Spain

Status

Recruiting

Source

Roxall Medizin

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-07-24T14:10:56-0400

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PubMed Articles [7056 Associated PubMed Articles listed on BioPortfolio]

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Medical and Biotech [MESH] Definitions

Antigens from the house dust mites (DERMATOPHAGOIDES), mainly D. farinae and D. pteronyssinus. They are proteins, found in mite feces or mite extracts, that can cause ASTHMA and other allergic diseases such as perennial rhinitis (RHINITIS, ALLERGIC, PERENNIAL) and atopic dermatitis (DERMATITIS, ATOPIC). More than 11 groups of Dermatophagoides ALLERGENS have been defined. Group I allergens, such as Der f I and Der p I from the above two species, are among the strongest mite immunogens in humans.

Family of house dust mites, in the superfamily Analgoidea, order Astigmata. They include the genera Dermatophagoides and Euroglyphus.

Species of European house dust mite, in the family PYROGLYPHIDAE. It is the most commonly found house dust mite.

Family of MITES in the superfamily Trombiculoidea, suborder Prostigmata, which attack humans and other vertebrates, causing DERMATITIS and severe allergic reactions. Chiggers, red bugs, and harvest mites commonly refer to the larval stage of Trombiculid mites, the only parasitic stage of the mite's life cycle.

Earth or other matter in fine, dry particles. (Random House Unabridged Dictionary, 2d ed)

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The term allergy is used to describe a response, within the body, to a substance, which is not necessarily harmful in itself, but results in an immune response and a reaction that causes symptoms and disease in a predisposed person, which in turn can cau...


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