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Acute Montelukast in Asthma

2014-08-27 03:18:03 | BioPortfolio

Summary

Patients presenting to hospital with an acute asthma exacerbation severe enough to require admission would receive full standard treatment according to British Thoracic Society guidelines in addition they would be offered the opportunity to take part in the study which would requite them to take a capsule of either montelukast or placebo.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Conditions

Acute Asthma Exacerbation

Intervention

Montelukast, Placebo

Location

Norfolk and Norwich University Hospital
Norwich
United Kingdom
NR47UY

Status

Completed

Source

University of East Anglia

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:18:03-0400

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Effect of Addition of Oral Montelukast to Standard Treatment in Acute Moderate to Severe Asthma in Children

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Pragmatic RCT of High-dose Montelukast for Pediatric Asthma Exacerbations

Trials of IV montelukast for adults with moderate and severe acute asthma exacerbations have demonstrated rapid and sustained, clinically meaningful improvements of %-predicted FEV1. Studi...

Asthma in the Elderly: The Effect of Montelukast

This is a pilot study of the effect of montelukast in subjects with asthma who are 65 years old and older. Montelukast is a leukotriene receptor antagonist U.S. F.D.A. approved for the tre...

PubMed Articles [7698 Associated PubMed Articles listed on BioPortfolio]

Systematic Review and Content Analysis of Asthma Knowledge Questionnaires: A Focus on Knowledge Surrounding Acute Exacerbation Management.

Objectives Asthma education is a key component of asthma management. Asthma education around management of a person who is having an acute exacerbation of asthma (often referred to as asthma first-aid...

Economic analysis of the Phase III MENSA study evaluating mepolizumab for severe asthma with eosinophilic phenotype.

Severe eosinophilic asthma patients are at risk of exacerbations, which are associated with substantial costs. Mepolizumab lowers eosinophil levels and reduces exacerbation risk in severe eosinophilic...

Management of acute asthma exacerbations.

Herein, we review the current guidelines for the management of children with an acute asthma exacerbation. We focus on management in the emergency department, inpatient, and ICU settings.

Shared Decision Making and Time to Exacerbation in Children with Asthma.

Although shared decision making (SDM) is a promising approach for improving outcomes for patients with chronic diseases, no evidence currently supports the use of SDM to delay asthma exacerbations. We...

Efficacy and safety of HL301 in the treatment of acute bronchitis and acute exacerbation of chronic bronchitis: a phase 2, randomized, double-blind, placebo-controlled, multicenter study.

Purpose The efficacy and safety of Chinese herbs for symptomatic treatment of bronchitis is not well established. We evaluated the efficacy and safety of a combination product of seven herbs (HL301) f...

Medical and Biotech [MESH] Definitions

A transient exacerbation of symptoms of an existing disease or condition.

Asthma attacks caused, triggered, or exacerbated by OCCUPATIONAL EXPOSURE.

Misunderstanding among individuals, frequently research subjects, of scientific methods such as randomization and placebo controls.

A disease of young infants characterized by soft tissue swellings over the affected bones, fever, and irritability, and marked by periods of remission and exacerbation. (Dorland, 27th ed)

An effect usually, but not necessarily, beneficial that is attributable to an expectation that the regimen will have an effect, i.e., the effect is due to the power of suggestion.

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