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The question of whether the hemoglobin concentration itself accurately represents the underlying red cell mass in elderly patients with anemia has not previously been addressed. This question has arisen because the clinical consequences of seemingly trivial levels of anemia are surprisingly severe. We wish to test this hypothesis by measuring the true red cell mass and plasma volume in elderly with anemia and compare this value with the routine clinical measurement of hemoglobin.
Patients will be enrolled from the "Anemia in the Elderly" study and thus will already have had a full hematologic evaluation for their anemia. They will have a complete blood count as part of this evaluation. After enrolling, they will have red blood cell mass and plasma volume measurements performed either at California Pacific Medical Center (CPMC) as per standard clinical practice or at Stanford Hospital and Clinics if this test becomes available at Stanford. We are in discussions with Dr. Michael Goris from Nuclear Medicine re: the possibility of having this test available here at Stanford. Tests will be scheduled as routine clinical tests at this institution (requiring approximately 2 weeks scheduling time). Red blood cell mass will be measured from the dilution of chromium-51 (51 Cr) labeled autologous fresh RBCs in the patient's blood volume. The plasma volume will be measured with labeled albumin.
On the same day as these tests, subjects will also give a blood sample (10 cc) for the following tests: complete blood count (CBC), spun hematocrit and serum erythropoietin level. They will also have their height and weight measured.
Observational Model: Cohort, Time Perspective: Prospective
Stanford University School of Medicine
Published on BioPortfolio: 2014-07-23T21:11:50-0400
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