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The purpose of this study is to clarify the physiological function of sodium glutamate by measuring its effect on upper GI motility (esophageal manometry, impedance and gastric emptying).
Amino acids such as monosodium glutamate are known to stimulate both endocrine and exocrine secretion. In addition, there is a report that oral intake of glutamate evokes the activation of vagal afferent nerves in the rat. Thus, such amino acids are thought to be influential in the process of digestion and absorption.
Transient lower esophageal sphincter relaxation (TLESR) is the major mechanism of gastroesophageal reflux. TLESR is triggered by gastric distention, leading to activation of a reflex pathway involving gastric vagal afferents, brainstem centers, and inhibitory efferents to the lower esophageal sphincter.
To investigate the effect of monosodium glutamate on gastrointestinal motility, we planned a single-blind randomized study. The participants will take either monosodium glutamate or sodium chloride before the first examination of upper GI motility and the other agent before the second examination. The order of intake will be randomized by the envelope method.
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Single Blind (Subject), Primary Purpose: Basic Science
Monosodium glutamate, Sodium chloride
Gunma university hospital
Active, not recruiting
Published on BioPortfolio: 2014-08-27T03:18:08-0400
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