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MSG and Gastrointestinal Motility

2014-08-27 03:18:08 | BioPortfolio

Summary

The purpose of this study is to clarify the physiological function of sodium glutamate by measuring its effect on upper GI motility (esophageal manometry, impedance and gastric emptying).

Description

Amino acids such as monosodium glutamate are known to stimulate both endocrine and exocrine secretion. In addition, there is a report that oral intake of glutamate evokes the activation of vagal afferent nerves in the rat. Thus, such amino acids are thought to be influential in the process of digestion and absorption.

Transient lower esophageal sphincter relaxation (TLESR) is the major mechanism of gastroesophageal reflux. TLESR is triggered by gastric distention, leading to activation of a reflex pathway involving gastric vagal afferents, brainstem centers, and inhibitory efferents to the lower esophageal sphincter.

To investigate the effect of monosodium glutamate on gastrointestinal motility, we planned a single-blind randomized study. The participants will take either monosodium glutamate or sodium chloride before the first examination of upper GI motility and the other agent before the second examination. The order of intake will be randomized by the envelope method.

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Single Blind (Subject), Primary Purpose: Basic Science

Conditions

Gastroesophageal Reflux

Intervention

Monosodium glutamate, Sodium chloride

Location

Gunma university hospital
Maebashi
Gunma
Japan
3718511

Status

Active, not recruiting

Source

Gunma University

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:18:08-0400

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Medical and Biotech [MESH] Definitions

Retrograde bile flow. Reflux of bile can be from the duodenum to the stomach (DUODENOGASTRIC REFLUX); to the esophagus (GASTROESOPHAGEAL REFLUX); or to the PANCREAS.

Sodium or sodium compounds used in foods or as a food. The most frequently used compounds are sodium chloride or sodium glutamate.

Back flow of gastric contents to the LARYNGOPHARYNX where it comes in contact with tissues of the upper aerodigestive tract. Laryngopharyngeal reflux is an extraesophageal manifestation of GASTROESOPHAGEAL REFLUX.

A subclass of symporters that specifically transport SODIUM CHLORIDE and POTASSIUM CHLORIDE across cellular membranes in a tightly coupled process.

Agents that inhibit SODIUM CHLORIDE SYMPORTERS. They act as DIURETICS. Excess use is associated with HYPOKALEMIA.

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