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Azithromycin in Bronchiolitis Obliterans Syndrome

2014-08-27 03:18:08 | BioPortfolio

Summary

Preventive treatment with azithromycin reduces the prevalence fo Bronchiolitis Obliterans Syndrome after lung transplantation.

Description

- Prospective, interventional, randomized, double-blind, placebo-controlled trial.

- Clinical setting (tertiary University Hospital).

- Investigator-driven, no pharmaceutical sponsor.

- Lung transplant recipients.

- Add-on of study-drug (placebo or azithromycin) to 'standard of care' (standardized, routine immunosuppressive and infectious prophylactic protocol).

- 1:1 inclusion ratio (placebo:azithromycin).

- Randomisation at discharge after informed consent.

Study Design

Allocation: Randomized, Control: Placebo Control, Intervention Model: Single Group Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Prevention

Conditions

Bronchiolitis Obliterans Syndrome

Intervention

Azithromycin, Placebo

Location

Katholieke Universiteit Leuven and University Hospital Gasthuisberg
Leuven
Belgium
B-3000

Status

Active, not recruiting

Source

Katholieke Universiteit Leuven

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:18:08-0400

Clinical Trials [1347 Associated Clinical Trials listed on BioPortfolio]

Early Detection and Management of Bronchiolitis Obliterans Syndrome Following Pediatric Hematopoietic Stem Cell Transplantation

This study aims to determine whether or not early spirometric detection and management of obstructive lung disease with combined fluticasone/azithromycin/montelukast therapy (FAM) can atte...

Effectiveness of Azithromycin Therapy in Improvement of Symptoms and Lung Function in Patients With Bronchiolitis Obliterans After Bone Marrow Transplantation

Bronchiolitis obliterans syndrome (BOS), an obstructive airway disease as a result of chronic rejection, is one of the major causes of morbidity and mortality in long-term survivors of all...

Azithromycin to Prevent Wheezing Following Severe RSV Bronchiolitis-II

The main objective of the APW-RSV II clinical trial is to evaluate if the addition of azithromycin to routine bronchiolitis care, among infants hospitalized with RSV bronchiolitis, reduces...

Extracorporeal Photopheresis in Patients With Bronchiolitis Obliterans Syndrome (BOS) After Lung Transplantation

Investigation of photopheresis as new therapy regimen in patients with bronchiolitis obliterans syndrome after lung transplantation in a controlled, randomized study

Sleep Disorders in Bronchiolitis Obliterans Syndrome 2&3

This study is to determine whether sleep disorders contribute to impaired quality of life and mobility in patients with Bronchiolitis Obliterans syndrome and whether non invasive positive...

PubMed Articles [5705 Associated PubMed Articles listed on BioPortfolio]

EXTRACORPOREAL PHOTOPHERESIS FOR BRONCHIOLITIS OBLITERANS SYNDROME AFTER LUNG TRANSPLANTATION.

Lung transplantation is a therapeutic option for select patients with end-stage lung disease. However, successful lung transplantation is hampered by chronic lung allograft dysfunction (CLAD), in part...

Double lung, unlike single lung transplantation might provide a protective effect on mortality and bronchiolitis obliterans syndrome.

Survival after lung transplantation (LTx) is often limited by bronchiolitis obliterans syndrome (BOS).

Inert gas washout in bronchiolitis obliterans following hematopoietic cell transplantation.

Bronchiolitis obliterans (BO) syndrome is a leading cause of chronic graft-versus-host disease (cGvHD) and is associated with mortality after allogeneic hematopoietic stem cell transplantation (alloHC...

Montelukast for bronchiolitis obliterans syndrome after lung transplantation: A randomized controlled trial.

Bronchiolitis obliterans syndrome (BOS) remains the major problem which precludes long-term survival after lung transplantation. Previously, an open label pilot study from our group demonstrated a pos...

Health-related quality of life in patients with bronchiolitis obliterans.

To evaluate the overall health-related quality of life in patients with bronchiolitis obliterans.

Medical and Biotech [MESH] Definitions

Inflammation of the BRONCHIOLES leading to an obstructive lung disease. Bronchioles are characterized by fibrous granulation tissue with bronchial exudates in the lumens. Clinical features include a nonproductive cough and DYSPNEA.

A non-atherosclerotic, inflammatory thrombotic disease that commonly involves small and medium-sized arteries or veins in the extremities. It is characterized by occlusive THROMBOSIS and FIBROSIS in the vascular wall leading to digital and limb ISCHEMIA and ulcerations. Thromboangiitis obliterans is highly associated with tobacco smoking.

A semi-synthetic macrolide antibiotic structurally related to ERYTHROMYCIN. It has been used in the treatment of Mycobacterium avium intracellulare infections, toxoplasmosis, and cryptosporidiosis.

Inflammation of the BRONCHIOLES.

Misunderstanding among individuals, frequently research subjects, of scientific methods such as randomization and placebo controls.

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