Advertisement

Topics

Concentrations of Maraviroc in the Semen of HIV-Infected Men

2014-08-27 03:18:09 | BioPortfolio

Summary

The objective of this study is to determine if concentrations of maraviroc in semen exceed the 50% and 95% inhibitory concentrations of HIV during the dose interval.

The secondary objective is to determine the extent of maraviroc penetration into semen by obtaining semen to plasma ratios across the dosing interval, to determine the area under the concentration time curve of maraviroc in semen, and to determine the variability in the penetration of maraviroc into the seminal compartment over the raltegravir dosing period.

Description

The patient population will consist of 12 male HIV-positive patients who have been receiving stable antiretroviral therapy that includes maraviroc for a minimum of three months. Patients will be enrolled from one clinic in downtown Toronto and a hospital affiliated HIV specialty clinic in Ottawa, Ontario. Eligible patients will have evidence of full virologic suppression (HIV viral load < 50 copies/mL) at least one month prior to enrollment in the study. No changes will be made to the patients antiretroviral therapy during the course of the study.

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Conditions

Maraviroc Concentrations in Semen

Intervention

Measuring semen samples

Location

Canadian Immunodeficiency Research Collaborative
Toronto
Ontario
Canada
M5B1L6

Status

Recruiting

Source

Canadian Immunodeficiency Research Collaborative

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:18:09-0400

Clinical Trials [787 Associated Clinical Trials listed on BioPortfolio]

Concentrations of Raltegravir in the Semen of HIV-Infected Men

The objective of this study is to determine if concentrations of raltegravir in semen exceed the 50% and 95% inhibitory concentrations of HIV during the dose interval. The secondary objec...

Oxidative Stress In Semen And Male Infertility

The proposed research aims to study the effects of antioxidant therapy, commonly used in male infertility treatment, on semen analysis. Patients presenting with male infertility, who are f...

In Vitro Effects of Procyanidine on Semen Parameter and DFI

Proanthocyanidins are a class of polyphenols found in a variety of plants that have antioxidant activity in vitro, which is stronger than vitamin C or vitamin E. Several studies have been...

Semen Analysis After Proton Therapy for Prostate Cancer

The purpose of this study is to evaluate semen for changes following radiation treatment with proton beam radiotherapy alone. The semen samples will be compared for sperm count, sperm move...

Effect of Different Sperm Processing Methods in ICSI Outcome.

A total 180 semen samples from couples diagnosed with unexplained infertility were SDF index tested , then total 120 semen samples of patients' husbands with abnormal SDF index were random...

PubMed Articles [11671 Associated PubMed Articles listed on BioPortfolio]

High abundances of the nuisance raphidophyte Gonyostomum semen in brown water lakes are associated with high concentrations of iron.

Algal blooms occur frequently in lakes and oceans and the causes and consequences of those are often studied. In this study, we focus on a less well known type of algal bloom by the freshwater raphido...

Economic evaluation of sexed semen use in Iranian dairy farms according to field data.

In this study, at first, the reproductive consequences of sexed semen use were quantified and then the cost-benefit of sexed semen use on Iranian commercial dairy farms was evaluated. Retrospective da...

Variables affecting semen quality and its relation to fertility in the dog: A retrospective study.

Although semen analysis is routinely used to evaluate the male reproductive potential in the canine species, only a few authors have attempted to relate semen characteristics to donor traits, such as ...

Effects of different doses of eugenol on plasma cortisol levels and the quality of fresh and frozen-thawed sperm in South American catfish (Rhamdia quelen).

The production of captive fish is only possible through artificial reproduction, but manipulation is a known stressor stimulus. Thus, the objective of the present study was to evaluate the effects of ...

Isolation and Detection of Mycoplasma agalactiae from Semen Samples of Goats.

Contagious agalactia (CA) is a highly infectious disease of goats and sheep, and is a form of Mycoplasmosis, which is usually enzootic. Since Mycoplasma agalactiae (M. agalactiae) is the main cause of...

Medical and Biotech [MESH] Definitions

The quality of SEMEN, an indicator of male fertility, can be determined by semen volume, pH, sperm concentration (SPERM COUNT), total sperm number, sperm viability, sperm vigor (SPERM MOTILITY), normal sperm morphology, ACROSOME integrity, and the concentration of WHITE BLOOD CELLS.

A condition characterized by the complete absence of SEMEN. This disorder should be differentiated from AZOOSPERMIA, absence of sperm in the semen.

The process by which semen is kept viable outside of the organism from which it was derived (i.e., kept from decay by means of a chemical agent, cooling, or a fluid substitute that mimics the natural state within the organism).

A condition of suboptimal concentration of SPERMATOZOA in the ejaculated SEMEN to ensure successful FERTILIZATION of an OVUM. In humans, oligospermia is defined as a sperm count below 20 million per milliliter semen.

A condition of having no sperm present in the ejaculate (SEMEN).

More From BioPortfolio on "Concentrations of Maraviroc in the Semen of HIV-Infected Men"

Advertisement
Quick Search
Advertisement
Advertisement

 

Relevant Topics

Human Immuno Deficiency Virus (HIV)
Human Immunodeficiency Virus (HIV), the causative agent of AIDS. The Human Immunodeficiency Virus, more commonly known as HIV, is a member of the lentivirus sub-set of the retrovirus family of pathogens. It causes AIDS, or Acquired Immuno Deficiency Sy...

Blood
Blood is a specialized bodily fluid that delivers necessary substances to the body's cells (in animals) – such as nutrients and oxygen – and transports waste products away from those same cells.  In vertebrates, it is composed of blo...


Searches Linking to this Trial