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RCT for the Treatment of Acute Asthma in Wheezy Pre-school Aged Children

2014-08-27 03:18:09 | BioPortfolio

Summary

To determine if treatment of pre-school children with a history of wheeze who present to an ED with an acute wheezing episode with azithromycin for 5 days will resolve their symptoms more quickly, will require less SABA, and allow these children to remain symptom free for a longer period of time.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Conditions

Asthma

Intervention

Azithromycin, Placebo

Location

Alberta Children's Hospital
Calgary
Alberta
Canada
T3B 6A8

Status

Not yet recruiting

Source

Alberta Children's Hospital

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:18:09-0400

Clinical Trials [1443 Associated Clinical Trials listed on BioPortfolio]

AZISAST Study: AZIthromycin in Severe ASThma Study

The purpose of this study is to evaluate the efficacy, safety and cost-effectiveness of azithromycin as add-on therapy in adult subjects with severe persistent asthma, who remain inadequat...

ASTHMA (AntibioticS To Help Manage Asthma) Pilot Study

The ASTHMA Pilot Study is a randomized, controlled, parallel group clinical trial of 6 weekly doses of azithromycin (cumulative dose 4800 mg) or placebo as adjunctive treatment in addition...

Childhood Asthma Research and Education (CARE) Network Trial - Montelukast or Azithromycin for Reduction of Inhaled Corticosteroids in Childhood Asthma (MARS)

The MARS trial is a randomized, double-blind, parallel group study that compares the capacity of azithromycin or montelukast to placebo as effective adjunctive therapy that allows reductio...

AZMATICS: AZithroMycin/Asthma Trial In Community Settings

The purpose of this study is to determine whether an emerging body of evidence suggests that half of adult asthma cases may be caused by chronic infection that is treatable with antibiotic...

Local Pharmacokinetics of Azithromycin Eye Drops in Healthy Volunteers

To compare the pharmacokinetic behavior of azithromycin eye drops in the tear with the original azithromycin eye drops, and evaluate the release behavior of both in the eye.

PubMed Articles [1738 Associated PubMed Articles listed on BioPortfolio]

Effect of azithromycin on asthma exacerbations and quality of life in adults with persistent uncontrolled asthma (AMAZES): a randomised, double-blind, placebo-controlled trial.

Exacerbations of asthma cause a substantial global illness burden. Adults with uncontrolled persistent asthma despite maintenance treatment require additional therapy. Since macrolide antibiotics can ...

A Double-Blind Randomized Placebo-Controlled Pilot Study of Azithromycin in Youth with Acute-Onset Obsessive-Compulsive Disorder.

Sudden and severe onset of obsessive-compulsive disorder (OCD) may present secondary to infectious and/or immune-mediated triggers. We assessed the preliminary efficacy, tolerability, and safety of az...

Azithromycin in uncontrolled asthma.

Oral Glucocorticoid-Sparing Effect of Benralizumab in Severe Asthma.

Background Many patients with severe asthma rely on oral glucocorticoids to manage their disease. We investigated whether benralizumab, a monoclonal antibody directed against the alpha subunit of the ...

Azithromycin reduced exacerbations and improved QoL in symptomatic asthma despite inhaled maintenance therapy.

Medical and Biotech [MESH] Definitions

A semi-synthetic macrolide antibiotic structurally related to ERYTHROMYCIN. It has been used in the treatment of Mycobacterium avium intracellulare infections, toxoplasmosis, and cryptosporidiosis.

Asthma attacks caused, triggered, or exacerbated by OCCUPATIONAL EXPOSURE.

Misunderstanding among individuals, frequently research subjects, of scientific methods such as randomization and placebo controls.

An effect usually, but not necessarily, beneficial that is attributable to an expectation that the regimen will have an effect, i.e., the effect is due to the power of suggestion.

Asthma attacks following a period of exercise. Usually the induced attack is short-lived and regresses spontaneously. The magnitude of postexertional airway obstruction is strongly influenced by the environment in which exercise is performed (i.e. inhalation of cold air during physical exertion markedly augments the severity of the airway obstruction; conversely, warm humid air blunts or abolishes it).

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