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Opioid medications are commonly used for pain relief. When given over time, physical dependence can occur. This results in unpleasant side effects--such as agitation and nausea--if opioid medications are suddenly stopped. However, we do not know how withdrawal affects the brain. We know that a medication named Ondansetron can help ease or prevent symptoms associated with opioid withdrawal. Through imaging of the brain by fMRI, we hope to see how opioid withdrawal, with and without the administration of ondansetron, affects brain activity.
Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Caregiver, Outcomes Assessor), Primary Purpose: Treatment
Stanford University School of Medicine
Enrolling by invitation
Published on BioPortfolio: 2014-08-27T03:18:15-0400
The purpose of this study is to assess ondansetron for the treatment of methamphetamine dependence.
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This chapter reviews antidepressant treatment considerations and recommendations for patients with co-occurring depression and substance use disorders. Depression and substance use disorders are highl...
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A medical specialty focused on the diagnosis and treatment of ADDICTIVE BEHAVIOR disorders, including SUBSTANCE-RELATED DISORDERS and IMPULSE CONTROL DISORDERS; and the management of co-occurring medical and psychiatric conditions
These disorders are related to both SCHIZOPHRENIA SPECTRUM AND RELATED DISORDERS and DEPRESSIVE DISORDERS in terms of symptomatology, family history, and genetics. (DSM-V) .
Psychotic organic mental disorders resulting from the toxic effect of drugs and chemicals or other harmful substance.
Disorders related or resulting from abuse or mis-use of opioids.
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Pharmacy is the science and technique of preparing as well as dispensing drugs and medicines. It is a health profession that links health sciences with chemical sciences and aims to ensure the safe and effective use of pharmaceutical drugs. The scope of...