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fMRI Imaging of Opioid Withdrawal in Healthy Human Volunteers

2014-08-27 03:18:15 | BioPortfolio

Summary

Opioid medications are commonly used for pain relief. When given over time, physical dependence can occur. This results in unpleasant side effects--such as agitation and nausea--if opioid medications are suddenly stopped. However, we do not know how withdrawal affects the brain. We know that a medication named Ondansetron can help ease or prevent symptoms associated with opioid withdrawal. Through imaging of the brain by fMRI, we hope to see how opioid withdrawal, with and without the administration of ondansetron, affects brain activity.

Study Design

Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Caregiver, Outcomes Assessor), Primary Purpose: Treatment

Conditions

Substance-Related Disorders

Intervention

Ondansetron

Location

Stanford University School of Medicine
Stanford
California
United States
94305

Status

Enrolling by invitation

Source

Stanford University

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:18:15-0400

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Medical and Biotech [MESH] Definitions

Disorders related to substance abuse, the side effects of a medication, toxin exposure, and ALCOHOL-RELATED DISORDERS.

These disorders are related to both SCHIZOPHRENIA SPECTRUM AND RELATED DISORDERS and DEPRESSIVE DISORDERS in terms of symptomatology, family history, and genetics. (DSM-V) .

Psychotic organic mental disorders resulting from the toxic effect of drugs and chemicals or other harmful substance.

Disorders related or resulting from abuse or mis-use of opioids.

Disorders related or resulting from use of amphetamines.

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