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Study of SCH 527123 in Subjects With Severe Asthma (Study P05109AM1)

2014-10-27 22:01:36 | BioPortfolio

Published on BioPortfolio: 2014-10-27T22:01:36-0400

Clinical Trials [1391 Associated Clinical Trials listed on BioPortfolio]

Long-Term Extension Study of the Effects of SCH 527123 in Subjects With Moderate to Severe COPD

Neutrophils are thought to play an important role in the pathophysiology of COPD. It is theorized that reducing neutrophil migration to the diseased lung will improve a subject's symptoms...

Two-Part Study to Evaluate the Dose Response of SCH 527123 on Sputum Neutrophilia Following Ozone Challenge in Healthy Subjects and Chronic Obstructive Pulmonary Disease (COPD) Patients (P05567 AM7)

Trial to evaluate the dose response of SCH 527123 in reducing inflammation from an ozone-induced sputum neutrophilia in both healthy subjects and subjects with COPD.

Efficacy and Safety of SCH 527123 in Subjects With Allergen-Induced Asthma (Study P05363)(COMPLETED)

Evaluation of treatment in subjects with mild asthma.

Study to Evaluate the Safety and Dose-Range of SCH 527123 in Subjects With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD) (Study P04592AM4)(COMPLETED)

This is a two-part study conducted at multiple centers, in subjects with moderate to severe COPD. Part 1 of the study is a double-blind, placebo-controlled, randomized, rising-dose study ...

Neutrophilic Asthma Study With SCH 527123 (Study P05365AM2)(COMPLETED)

4-Week Safety Study in Subjects with Neutrophilic Asthma

PubMed Articles [1037 Associated PubMed Articles listed on BioPortfolio]

Update: Asthma Yardstick: Practical recommendations for a sustained step-up in asthma therapy for poorly controlled asthma.

Favorable response to asthma-dosed subcutaneous mepolizumab in eosinophilic pneumonia.

Mepolizumab targets eosinophils in the treatment of asthma. The dose used for asthma is considerably lower than that used for treating eosinophilic granulomatosis with polyangiitis, a recently approve...

Treatment patterns and related clinical consequences in adults with asthma.

A stepwise therapeutic management is recommended for asthma patients by the Global Initiative for Asthma (GINA). Little is known about the recommendations applied in real world settings. This study ai...

Seasonal changes influence the improvement in asthma symptoms by exercise training in subjects with asthma.

To investigate whether patients with moderate to severe asthma who commence an exercise training program in winter or summer show differences in exercise capacity, health-related quality of life (HRQo...

Characterisation of asthma in the adolescent population.

Asthma often debuts in early life (1). During childhood, the prevalence of asthma is higher in boys, but prevalence is higher in girls after puberty (2). The goal of asthma treatment is to achieve and...

Medical and Biotech [MESH] Definitions

Asthma attacks caused, triggered, or exacerbated by OCCUPATIONAL EXPOSURE.

Asthma attacks following a period of exercise. Usually the induced attack is short-lived and regresses spontaneously. The magnitude of postexertional airway obstruction is strongly influenced by the environment in which exercise is performed (i.e. inhalation of cold air during physical exertion markedly augments the severity of the airway obstruction; conversely, warm humid air blunts or abolishes it).

Drugs that are used to treat asthma.

A beta-adrenergic agonist used in the treatment of asthma and bronchospasms.

Adrenergic beta-2 agonist used as bronchodilator for emphysema, bronchitis and asthma.

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