A Trial of N-Acetylcysteine (an Over-the-Counter Medicine) in Adolescents Who Smoke Marijuana

2014-07-23 21:11:55 | BioPortfolio


This study is investigating how N-Acetylcysteine (NAC), an over-the-counter medication, will reduce marijuana use when combined with Contingency Management, a behavioral treatment. It is hypothesized that marijuana dependent adolescents who are treated with NAC will use less marijuana during treatment when compared to adolescents who receive a placebo.


This protocol involves investigation of N-Acetylcysteine (NAC) as a pharmacological treatment for cannabis dependence in adolescents. While recent advances have been made in psychosocial treatments for cannabis dependent adolescents, minimal work has been done to investigate the potential adjunctive role for pharmacotherapy in treatment. NAC is an inexpensive, over-the-counter agent with a favorable tolerability profile in adults and children, in common use since FDA approval in 1963. Preclinical and preliminary clinical research in adults suggests a role for NAC in addiction treatment via glutamate modulation.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment


Cannabis Dependence


N-Acetylcysteine, placebo, Contingency Management


Medical University of South Carolina
South Carolina
United States




Medical University of South Carolina

Results (where available)

View Results


Published on BioPortfolio: 2014-07-23T21:11:55-0400

Clinical Trials [982 Associated Clinical Trials listed on BioPortfolio]

An Open-Label Trial of N-Acetylcysteine in Cannabis Dependent Adolescents

The purpose of this pilot study is to determine the feasibility of conducting a trial of N-Acetylcysteine in cannabis dependent adolescents.

N-acetylcysteine for the Treatment of Cannabis Dependence: Working Mechanisms

We investigate the effects of repeated NAC administration on glutamate concentrations in the anterior cingulate cortex (ACC), on neurocognitive functioning, and on neuro-inflammatory param...

N-Acetylcysteine for Youth Cannabis Use Disorder

This is a 12-week randomized, placebo-controlled trial of N-acetylcysteine for cannabis use disorder (CUD) in youth (N=192). Participants will be randomized to double-blind NAC or PBO, yie...

Combination of Dronabinol and Clonidine for Cannabis Dependence in Patients With Schizophrenia

Cannabis use disorders are an important public health problem in the United States, but no effective pharmacotherapies are available to treat these disorders. People with schizophrenia ar...

Treatment for Cannabis Withdrawal and Dependence

Cannabis is the most widely used illicit drug in the United States, and worldwide, with 1 in 10 users estimated to meet diagnostic criteria for cannabis dependence. Avoidance of withdrawal...

PubMed Articles [9928 Associated PubMed Articles listed on BioPortfolio]

Biological correlates of self-reported new and continued abstinence in cannabis cessation treatment clinical trials.

The agreement between self-reported cannabis abstinence with urine cannabinoid concentrations in a clinical trials setting is not well characterized. We assessed the agreement between various cannabin...

The national implementation of Contingency Management (CM) in the Department of Veterans Affairs: Attendance at CM sessions and substance use outcomes.

In 2011, the Department of Veterans Affairs launched an initiative to expand patients' access to contingency management (CM) for the treatment of substance use disorders, particularly stimulant use di...

Understanding emerging forms of cannabis use through an online cannabis community: An analysis of relative post volume and subjective highness ratings.

Legalization of medical and recreational cannabis has coincided with an increase in novel forms of cannabis use and a burgeoning cannabis product industry. This research seeks to understand the occurr...

Initiation of vaporizing cannabis: Individual and social network predictors in a longitudinal study of young adults.

A trend has recently emerged of individuals using electronic nicotine delivery systems (ENDS) or similar devices to vaporize cannabis, either in the form of high-potency THC concentrates or cannabis p...

Growing practices and the use of potentially harmful chemical additives among a sample of small-scale cannabis growers in three countries.

With the growth of legal cannabis markets there has been recognition of the adverse impacts of certain cannabis growing practices, notably, use of harmful chemicals. A major concern has been the use o...

Medical and Biotech [MESH] Definitions

Coverage by contract whereby one part indemnifies or guarantees another against loss by a specified contingency.

Strong physiological and emotional dependence on OPIUM.

Strong dependence, both physiological and emotional, upon morphine.

Strong dependence, both physiological and emotional, upon heroin.

Participation of employees with management as a labor-management team, in decisions pertaining to the operational activities of the organization or industry.

More From BioPortfolio on "A Trial of N-Acetylcysteine (an Over-the-Counter Medicine) in Adolescents Who Smoke Marijuana"

Quick Search


Relevant Topics

Pharmacy is the science and technique of preparing as well as dispensing drugs and medicines. It is a health profession that links health sciences with chemical sciences and aims to ensure the safe and effective use of pharmaceutical drugs. The scope of...

Pediatrics is the general medicine of childhood. Because of the developmental processes (psychological and physical) of childhood, the involvement of parents, and the social management of conditions at home and at school, pediatrics is a specialty. With ...

Searches Linking to this Trial