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Safety Study of Human CNS Stem Cells Transplantation in Patients With Pelizaeus-Merzbacher Disease (PMD)

2014-08-27 03:18:16 | BioPortfolio

Summary

The purpose of this study is to determine the safety and preliminary effectiveness of human central nervous system stem cells (HuCNS-SC®) transplantation in patients with Connatal Pelizaeus-Merzbacher Disease (PMD). Enrolled subjects will be transplanted with HuCNS-SC cells into the brain and will receive immunosuppression for nine months. The study observation period is for one year after transplant surgery. Thereafter, subjects will be enrolled in a long-term observational follow-up study for four years.

Study Design

Allocation: Non-Randomized, Control: Uncontrolled, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label

Conditions

Connatal Pelizaeus-Merzbacher Disease (PMD)

Intervention

HuCNS-SC intracerebral transplantation

Location

University of California, San Francisco
San Francisco
California
United States
94143

Status

Recruiting

Source

StemCells, Inc.

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:18:16-0400

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Medical and Biotech [MESH] Definitions

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An organism that, as a result of transplantation of donor tissue or cells, consists of two or more cell lines descended from at least two zygotes. This state may result in the induction of donor-specific TRANSPLANTATION TOLERANCE.

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