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Prospective Randomized Comparison of Transurethral Resection by Mean of White Light and Narrow Band Imaging

2014-08-27 03:18:20 | BioPortfolio

Summary

To date, fluorescence and narrow band imaging cystoscopy have been tested in many prospective within patient trials but only as an "add on" procedure. This results in a bias that does not allow to determine the real impact of such innovative technologies on bladder cancer management. Hereby we propose the first prospective randomized trial which compares narrow band imaging trans urethral resection as a stand alone procedure versus white light transurethral resection. The primary end point is to assess the recurrence rate of bladder cancer lesions with each treatment modality. The study is designed to disclose an inferior recurrence rate (estimated 10%) in the group treated by narrow band imaging transurethral resection respect to the control group, treated by standard transurethral resection.

Study Design

Allocation: Randomized, Control: Active Control, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Non Muscle Invasive Bladder Cancer

Intervention

Narrow band imaging transurethral resection, Standard transurethral resection

Location

National Institute for Cancer Research (IST)
Genoa
Italy
16132

Status

Recruiting

Source

National Institute for Cancer Research, Italy

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:18:20-0400

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Medical and Biotech [MESH] Definitions

Complete or partial surgical removal of the prostate. Three primary approaches are commonly employed: suprapubic - removal through an incision above the pubis and through the urinary bladder; retropubic - as for suprapubic but without entering the urinary bladder; and transurethral (TRANSURETHRAL RESECTION OF PROSTATE).

Removal of all or part of the PROSTATE, often using a cystoscope and/or resectoscope passed through the URETHRA.

The only species in the genus GARDNERELLA, and previously classed as Haemophilus vaginalis. This bacterium, also isolated from the female genital tract of healthy women, is implicated in the cause of bacterial vaginosis (VAGINOSIS, BACTERIAL). It occasionally causes postpartum bacteremia and bacteremia following a transurethral resection of the prostate.

Imaging techniques that use illumination created with several optical interference filters by which the frequency ranges are spectrally narrowed and light scatter is greatly reduced. Thus the reflected photons reconstituting the images are from distinct depths (the surface and deeper layers) of the object being imaged.

Surgical removal or resection of the CERVIX UTERI.

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