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Study to Evaluate 13 C Isotope Ratio Measurement for Urea Cycle Capacity Assessment

2014-08-27 03:18:22 | BioPortfolio

Summary

In this short-term study a method for the evaluation of the metabolic competency of the urea cycle in vivo will be assessed. In order to monitor the efficacy of new treatment options for patients with urea cycle disorders and to monitor the severity of the disease, a reliable and safe quantitative method for the measurement of the urea cycle flux is required.

Urea synthesis will be evaluated by administering sodium [1-13C]-acetate and measuring subsequent incorporation of [13C] label from Na-acetate into urea in healthy volunteers and asymptomatic subjects genetically disposed to urea cycle disorders.

Study Design

Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic

Conditions

Urea Cycle Disorders

Intervention

sodium [1-13C] acetate

Location

CRS Clinical Research Services Mönchengladbach GmbH
Mönchengladbach
Germany
41061

Status

Completed

Source

Cytonet GmbH & Co. KG

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:18:22-0400

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Medical and Biotech [MESH] Definitions

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An amino acid produced in the urea cycle by the splitting off of urea from arginine.

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