Allopurinol Combination Study

2014-08-27 03:18:26 | BioPortfolio


To compare the proportion of subjects whose serum urate (sUA) levels are < 6.0 mg/dL following 4 weeks of continuous treatment of RDEA594 in combination with allopurinol to allopurinol alone in subjects with documented inadequate hypouricemic response with standard doses of allopurinol.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Factorial Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment




RDEA594, Placebo, Allopurinol


United States




Ardea Biosciences, Inc.

Results (where available)

View Results


Published on BioPortfolio: 2014-08-27T03:18:26-0400

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PubMed Articles [989 Associated PubMed Articles listed on BioPortfolio]

De-sensitization to allopurinol in a patient with tophi gout.

Allopurinol is a xanthine oxidase inhibitor used in the treatment of patients with gout. Approximately 2% of patients are affected by adverse reactions to this drug. Severity ranges from mild rashes t...

Febuxostat for the treatment of hyperuricaemia in gout.

Febuxostat is a potent non-purine selective xanthine oxidase inhibitor approved by the FDA in 2009 for management of hyperuricemia in people with gout. Areas covered: The authors summarize the pre-cli...

The Teratogenicity of Allopurinol: A comprehensive review of animal and human studies.

Allopurinol is widely used in the management of multiple disorders including gout, kidney stones and inflammatory bowel disease. Despite of long-term experience, its safety in pregnancy has been debat...

Budget impact of adding lesinurad for second-line treatment of gout: a US health plan perspective.

Estimate budget impact of adopting lesinurad as add-on to allopurinol for urate-lowering therapy in gout.

Can we predict inadequate response to allopurinol dose escalation? Analysis of a randomised controlled trial.

To determine factors that predict inadequate serum urate (SU) lowering response in a randomized controlled trial of allopurinol dose escalation (DE) in gout.

Medical and Biotech [MESH] Definitions

Agents that increase uric acid excretion by the kidney (URICOSURIC AGENTS), decrease uric acid production (antihyperuricemics), or alleviate the pain and inflammation of acute attacks of gout.

A XANTHINE OXIDASE inhibitor that decreases URIC ACID production. It also acts as an antimetabolite on some simpler organisms.

Misunderstanding among individuals, frequently research subjects, of scientific methods such as randomization and placebo controls.

An effect usually, but not necessarily, beneficial that is attributable to an expectation that the regimen will have an effect, i.e., the effect is due to the power of suggestion.

Uricosuric that acts by increasing uric acid clearance. It is used in the treatment of gout.

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