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Effects of the V1a Agonist FE 202158 in Patients With Septic Shock

2014-08-27 03:18:27 | BioPortfolio

Summary

The purpose of this trial is to examine the safety and tolerability, pharmacokinetics of FE202158 and to assess whether it can stabilize blood pressure and reduce vascular (blood vessel) leakage. FE 202158 has previously been tested in healthy volunteers.

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment

Conditions

Septic Shock

Intervention

FE 202158, Sodium Chloride

Location

Christiana Care Health System
Newark
Delaware
United States

Status

Recruiting

Source

Ferring Pharmaceuticals

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:18:27-0400

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Medical and Biotech [MESH] Definitions

A subclass of symporters that specifically transport SODIUM CHLORIDE and POTASSIUM CHLORIDE across cellular membranes in a tightly coupled process.

Agents that inhibit SODIUM CHLORIDE SYMPORTERS. They act as DIURETICS. Excess use is associated with HYPOKALEMIA.

Sodium chloride used in foods.

Sodium or sodium compounds used in foods or as a food. The most frequently used compounds are sodium chloride or sodium glutamate.

Agents that inhibit SODIUM-POTASSIUM-CHLORIDE SYMPORTERS which are concentrated in the thick ascending limb at the junction of the LOOP OF HENLE and KIDNEY TUBULES, DISTAL. They act as DIURETICS. Excess use is associated with HYPOKALEMIA and HYPERGLYCEMIA.

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