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Antibody Persistence & Immune Memory in Healthy Adults Previously Vaccinated With TwinrixTM Adult

2014-08-27 03:18:27 | BioPortfolio

Summary

This study will evaluate the persistence of the immune response to HAV (hepatitis A virus) antigens and HBs (hepatitis B surface) antigens in healthy adults previously vaccinated with GSK Biologicals' TwinrixTM Adult. The subjects will be invited for blood sampling 16, 17, 18, 19 and 20 years after vaccination to evaluate the antibody persistence. For subjects in whom low circulating antibodies are detected, the presence of immune memory against hepatitis A & B antigens will be investigated by the administration of a challenge dose of the appropriate vaccine (HavrixTM and/or EngerixTM-B) at the next planned visit.

No new subjects will be recruited during this study.

Study Design

Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Prevention

Conditions

Hepatitis A

Intervention

Blood sampling, Havrix, EngerixTM-B

Location

GSK Investigational Site
Wilrijk
Belgium
2610

Status

Recruiting

Source

GlaxoSmithKline

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:18:27-0400

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