PDS*Plus and Wound Infections After Laparotomy

2014-08-27 03:18:33 | BioPortfolio


The aim of this study is to ascertain if the use of PDS plus® reduces the number of wound infections and incisional hernia after midline and transverse laparotomy comparing to polyglactin suture.


All patients are treated using clinical pathways (CP) to standardise surgical procedures in our high volume centre. Part of the clinical process management was the standardisation of wound incision and abdominal wall closure.

Wound closure is achieved using continuous absorbable loop suture. The suture length to incision length ratio is at least 4:1. The running sutures are 1 cm apart and at least 1.5 cm from the wound edge. In the first time period (time period one, TP1), the CP step for fascia closure foresees a triclosan-coated polyglactin 910 loop suture (PDS plus®, Ethicon GmbH, Norderstedt, Germany). In the second time period the CP step will be altered to the use of PDS loop suture (PDS II®, Ethicon GmbH, Norderstedt, Germany). The primary outcome is the number of wound infections. Together with this the number of incisional hernia will be recorded. Patients demographic and disease as well as procedure related data are collected in a clinical information system (ISHmed on SAP platform, GSD, Berlin, Germany) prospectively. Risk factors for poor wound healing, such as operation time, patients age, sex, body mass index, blood loss, peritonitis, antibiotics, and performance level classified according to the American Society of Anesthesiologists (ASA), are collected prospectively to compare the two groups.

Study Design

Allocation: Non-Randomized, Control: Active Control, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment


Wound Infection


PDS plus, PDS II


Department of General, Visceral, Vascular and Pediatric Surgery, University of Saarland,




University Hospital, Saarland

Results (where available)

View Results


Published on BioPortfolio: 2014-08-27T03:18:33-0400

Clinical Trials [903 Associated Clinical Trials listed on BioPortfolio]

PICO Above Incisions After Vascular Surgery

The wound infection rate in the groin after vascular surgery has been denoted to be high since the wound surveillance register started in 2005. The current wound infection rate based on a ...

Topical Antibiotic Treatment for Spine Surgical Site Infection

There is considerable interest in using in-wound antibiotics (IWA) to prevent infection after spine surgery. An adequate evaluation of IWA is lacking and prior studies are limited by confo...

Wound Infection Alexis Wound Retractor

The purpose of this study is to determine whether the incidence of surgical site wound infection will be reduced in open appendectomy patients through the use of the Alexis® wound retract...

Supplemental Oxygen Reduces Surgical Infection

Supplemental perioperative oxygen has been reported to halve or double the risk of surgical wound infection. We tested the hypothesis that supplemental oxygen reduces infection risk follow...

Tracking Wound Infection With Smartphone Technology

This study aims to evaluate if a smartphone-delivered questionnaire can help assess for wound infections, and if this improves access to care and results in earlier treatment. Participants...

PubMed Articles [7422 Associated PubMed Articles listed on BioPortfolio]

Culture results from wound biopsy versus wound swab: does it matter for the assessment of wound infection?

The aim of this study was to determine whether assessment of wound infection differs when culture results from wound biopsy versus wound swab are available in clinical practice.

Prevention of deep sternal wound infection in cardiac surgery, review of literature.

Deep sternal wound infection is a dreaded complication of cardiac surgery with considerable consequences in terms of mortality, morbidity and treatment costs. Multiple specific measures in the prevent...

Selecting appropriate postoperative dressings to support wound healing and reduce surgical site infection.

The appropriate choice of postoperative dressing supports effective wound healing by providing a moist wound environment and reducing the risk of surgical site infection and blistering. Wound manageme...

Does the Use of Clean or Sterile Dressing Technique Affect the Incidence of Wound Infection?

The purpose of this article is to examine the evidence and provide recommendations for the use of clean or sterile dressing technique with dressing application to prevent wound infection.

Topical Nystatin Treatment for Candida Infection Following Wound Reconstruction.

Wound infection is an important cause of nonhealing wounds and graft rejection.

Medical and Biotech [MESH] Definitions

The application of a vacuum across the surface of a wound through a foam dressing cut to fit the wound. This removes wound exudates, reduces build-up of inflammatory mediators, and increases the flow of nutrients to the wound thus promoting healing.

Infection occurring at the site of a surgical incision.

Intraocular infection caused mainly by pus-producing bacteria and rarely by fungi. The infection may be caused by an injury or surgical wound (exogenous) or by endogenous septic emboli in such diseases as bacterial endocarditis or meningococcemia.

Invasion of the site of trauma by pathogenic microorganisms.

Removal of degenerated and necrotic epithelium and underlying connective tissue of a periodontal pocket in an effort to convert a chronic ulcerated wound to an acute surgical wound, thereby insuring wound healing and attachment or epithelial adhesion, and shrinkage of the marginal gingiva. The term is sometimes used in connection with smoothing of a root surface or ROOT PLANING. (Jablonski; Illustrated Dictionary of Dentistry, 1982)

More From BioPortfolio on "PDS*Plus and Wound Infections After Laparotomy"

Quick Search


Relevant Topics

Wound management
Anything that breaks the skin is a wound because when the skin is broken, there's a risk of germs getting into the body and causing an infection. Follow and track Wound Care News on BioPortfolio: Wound Car...

Antiretroviral Therapy Clostridium Difficile Ebola HIV & AIDS Infectious Diseases Influenza Malaria Measles Sepsis Swine Flu Tropical Medicine Tuberculosis Infectious diseases are caused by pathogenic...

Searches Linking to this Trial