Modified Ultrafiltration in Cardiac Surgery

2014-08-27 03:18:33 | BioPortfolio


The purpose of this study is to find out, whether filtration of the blood in patients undergoing cardiac surgery, beneficially influences the coagulation system.


The impact of modified ultrafiltration following extracorporeal circulation on primary and secondary hemostasis is controversial. In this study we intend to assess both, primary and secondary hemostasis prior to and after the usage of modified ultrafiltration. Primary hemostasis is assessed using Multiple Electrode Aggregometry (Multiplate) and secondary hemostasis is assessed performing thrombelastometry using the ROTEM device. Patients are preoperatively randomized to receive either modified ultrafiltration or no filtration.

Study Design

Observational Model: Cohort, Time Perspective: Prospective




modified ultrafiltration using Maquet haemoconcentrator, BC 20 plus


Goethe University hospital, Clinic for Anaesthesioloy
Frankfurt am Main




Goethe University

Results (where available)

View Results


Published on BioPortfolio: 2014-08-27T03:18:33-0400

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Medical and Biotech [MESH] Definitions

The separation of particles from a suspension by passage through a filter with very fine pores. In ultrafiltration the separation is accomplished by convective transport; in DIALYSIS separation relies instead upon differential diffusion. Ultrafiltration occurs naturally and is a laboratory procedure. Artificial ultrafiltration of the blood is referred to as HEMOFILTRATION or HEMODIAFILTRATION (if combined with HEMODIALYSIS).

Food derived from genetically modified organisms (ORGANISMS, GENETICALLY MODIFIED).

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A modified nucleoside which is present in the first position of the anticodon of tRNA-tyrosine, tRNA-histidine, tRNA-asparagine and tRNA-aspartic acid of many organisms. It is believed to play a role in the regulatory function of tRNA. Nucleoside Q can be further modified to nucleoside Q*, which has a mannose or galactose moiety linked to position 4 of its cyclopentenediol moiety.

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