Modified Ultrafiltration in Cardiac Surgery

2014-08-27 03:18:33 | BioPortfolio


The purpose of this study is to find out, whether filtration of the blood in patients undergoing cardiac surgery, beneficially influences the coagulation system.


The impact of modified ultrafiltration following extracorporeal circulation on primary and secondary hemostasis is controversial. In this study we intend to assess both, primary and secondary hemostasis prior to and after the usage of modified ultrafiltration. Primary hemostasis is assessed using Multiple Electrode Aggregometry (Multiplate) and secondary hemostasis is assessed performing thrombelastometry using the ROTEM device. Patients are preoperatively randomized to receive either modified ultrafiltration or no filtration.

Study Design

Observational Model: Cohort, Time Perspective: Prospective




modified ultrafiltration using Maquet haemoconcentrator, BC 20 plus


Goethe University hospital, Clinic for Anaesthesioloy
Frankfurt am Main




Goethe University

Results (where available)

View Results


Published on BioPortfolio: 2014-08-27T03:18:33-0400

Clinical Trials [432 Associated Clinical Trials listed on BioPortfolio]

Does Modified Ultrafiltration Affect Thromboelastography Results?

The study is to evaluate the effect of modified ultrafiltration on different components of Thromboelastography (TEG) in neonates undergoing cardiac surgery using cardiopulmonary bypass.

Does Modified Ultrafiltration Improves Inflammatory Response and Cardiopulmonary Function After CABG Procedures?

The inflammatory response after cardiac surgery increases mortality and morbidity. Modified ultrafiltration (MUF) has been shown to decrease the post-cardiac surgery inflammatory response,...

Coagulopathy in Cardiac Surgery

Coagulopathy in cardiac surgery; a quaternary-care academic center experience Objectives: Primary: To determine incidence of coagulopathy after cardiac surgery in Thai people To d...

Preop Hemodialysis or Intraop Ultrafiltration for Patients With Severe Renal Dysfunction Undergoing Open Heart Surgery

The purpose of this study is to determine whether preoperative hemodialysis or intraoperative modified ultrafiltration are effective for patients with non-dialysis dependent severe renal d...

Peritoneal Ultrafiltration to Treat Congestive Heart Failure

The purpose of this study is to determine whether the treatment of peritoneal ultrafiltration can improve survival and quality of life of refractory congestive heart failure with special a...

PubMed Articles [3545 Associated PubMed Articles listed on BioPortfolio]

Modified Ultrafiltration and Serum Vancomycin Levels in Adult Cardiac Surgery: Is There a Need to Redose?

In Situ Cold Perfusion of the Liver on Cardiopulmonary Bypass: Coagulopathy and Its Correction: A Case Report.

We report a case of profound coagulopathy after the dual insult of cold in-situ perfusion of the liver and cardiopulmonary bypass in a patient undergoing complex hepatobiliary and cardiovascular surge...

Efficient removal of nickel(II) from high salinity wastewater by a novel PAA/ZIF-8/PVDF hybrid ultrafiltration membrane.

The development of highly efficient membranes, especially those aimed at the removal of trace (ppm, 10) heavy metals from high salinity wastewater, is one of the principal challenges in the wastewater...

Ultrafiltration rate in conventional hemodialysis: Where are the limits and what are the consequences?

Ultrafiltration rate (UFR) has attracted attention as a modifiable aspect of volume management.

Rotational thromboelastometry in therapy of life threatening bleeding.

Bleeding and coagulopathy is a common problem in the fields of internal medicine. In case of life-threatening bleeding, rotational thromboelastometry (ROTEM) has critical role in diagnosis and therapy...

Medical and Biotech [MESH] Definitions

The separation of particles from a suspension by passage through a filter with very fine pores. In ultrafiltration the separation is accomplished by convective transport; in DIALYSIS separation relies instead upon differential diffusion. Ultrafiltration occurs naturally and is a laboratory procedure. Artificial ultrafiltration of the blood is referred to as HEMOFILTRATION or HEMODIAFILTRATION (if combined with HEMODIALYSIS).

Food derived from genetically modified organisms (ORGANISMS, GENETICALLY MODIFIED).

Extracorporeal ultrafiltration technique without hemodialysis for treatment of fluid overload and electrolyte disturbances affecting renal, cardiac, or pulmonary function.

Rapidly growing vascular lesion along the midline axis of the neck, upper trunk, and extremities that is characterized by CONSUMPTION COAGULOPATHY; THROMBOCYTOPENIA; and HEMOLYTIC ANEMIA. It is often associated with infantile Kaposiform HEMANGIOENDOTHELIOMA and other vascular tumors such as tufted ANGIOMA.

A modified nucleoside which is present in the first position of the anticodon of tRNA-tyrosine, tRNA-histidine, tRNA-asparagine and tRNA-aspartic acid of many organisms. It is believed to play a role in the regulatory function of tRNA. Nucleoside Q can be further modified to nucleoside Q*, which has a mannose or galactose moiety linked to position 4 of its cyclopentenediol moiety.

More From BioPortfolio on "Modified Ultrafiltration in Cardiac Surgery"

Quick Search


Relevant Topic

Surgical treatments
Surgery is a technology consisting of a physical intervention on tissues. All forms of surgery are considered invasive procedures; so-called "noninvasive surgery" usually refers to an excision that does not penetrate the structure being exci...

Searches Linking to this Trial