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Study of PKI-179 Administered Orally to Subjects With Solid Tumors

2014-07-23 21:12:26 | BioPortfolio

Summary

This is an open label dose escalation study to find the maximum tolerated dose (MTD) of PKI-179 in subjects with solid tumors. Part 1 of the study will be the dose estimation phase and will be open to subjects with all solid tumors. Part 2 will be the dose confirmation phase and will be open to subjects with breast, non small cell lung, ovarian, endometrial, or colorectal cancer or glioblastoma. All subjects will receive daily oral dosing of PKI-179. A continuous reassessment method (CRM) design will be used, which will take into account dose limiting toxicity (DLT) information from each dose level explored in order to determine the next dose level.

Study Design

Allocation: Non-Randomized, Endpoint Classification: Safety Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Advanced Malignant Solid Tumors

Intervention

PKI-179

Status

Terminated

Source

Wyeth

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-07-23T21:12:26-0400

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