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A Long-Term Safety and Tolerability Study of Bapineuzumab in Alzheimer Disease Patients

2014-08-27 03:18:35 | BioPortfolio

Summary

The purpose of this study is to assess the long-term safety and tolerability of bapineuzumab in subjects with Alzheimer Disease who participated in study 3133K1-3000 (NCT00667810). Over 250 sites will participate in over 26 countries outside of the United States. Subjects will receive bapineuzumab. Each subjects participation will last approximately 2 years.

Study Design

Allocation: Randomized, Endpoint Classification: Safety Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Conditions

Alzheimer Disease

Intervention

Bapineuzumab 0.5 mg/kg, Bapineuzumab 1.0 m/kg

Location

Adelaide
South Australia
Australia
5000

Status

Recruiting

Source

Wyeth

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:18:35-0400

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Abnormal structures located chiefly in distal dendrites and, along with NEUROFIBRILLARY TANGLES and SENILE PLAQUES, constitute the three morphological hallmarks of ALZHEIMER DISEASE. Neuropil threads are made up of straight and paired helical filaments which consist of abnormally phosphorylated microtubule-associated tau proteins. It has been suggested that the threads have a major role in the cognitive impairment seen in Alzheimer disease.

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