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Omega-3 Fatty Acids in Treating Patients With Advanced Prostate Cancer

2014-08-27 03:18:35 | BioPortfolio

Summary

RATIONALE: Omega-3 fatty acids may be able to slow disease progression and may be an effective treatment for patients with advanced cancer.

PURPOSE: This clinical trial studies omega-3 fatty acids in treating patients with advanced prostate cancer.

Description

OBJECTIVES:

- To conduct a feasibility study of omega-3 polysaturated fatty acid (PUFA) supplementation in patients with advanced prostate cancer.

- To assess the dose of omega-3 PUFA necessary to achieve an omega-6 to -3 ratio of 1:1 on an individual basis.

- Determine the clinical impact of omega-3 PUFA supplementation on disease progression.

OUTLINE: Patients receive long-term omega-3 polysaturated fatty acids (PUFA).

Patients undergo bone scans, DEXA scans, and blood and adipose sampling at baseline and at 1, 6, and 12 months. Patients also complete a 24-hour food-intake survey at the same time points to monitor dietary omega-6 PUFA intake.

Study Design

Masking: Open Label, Primary Purpose: Treatment

Conditions

Prostate Cancer

Intervention

omega-3 fatty acids, laboratory biomarker analysis, survey administration, bone scan, dual x-ray absorptometry

Status

Not yet recruiting

Source

Wake Forest University

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:18:35-0400

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Medical and Biotech [MESH] Definitions

FATTY ACIDS which have the first unsaturated bond in the sixth position from the omega carbon. A typical American diet tends to contain substantially more omega-6 than OMEGA-3 FATTY ACIDS.

A group of fatty acids, often of marine origin, which have the first unsaturated bond in the third position from the omega carbon. These fatty acids are believed to reduce serum triglycerides, prevent insulin resistance, improve lipid profile, prolong bleeding times, reduce platelet counts, and decrease platelet adhesiveness.

A group of fatty acids that contain 18 carbon atoms and a double bond at the omega 9 carbon.

FATTY ACIDS found in the plasma that are complexed with SERUM ALBUMIN for transport. These fatty acids are not in glycerol ester form.

Organic, monobasic acids derived from hydrocarbons by the equivalent of oxidation of a methyl group to an alcohol, aldehyde, and then acid. Fatty acids are saturated and unsaturated (FATTY ACIDS, UNSATURATED). (Grant & Hackh's Chemical Dictionary, 5th ed)

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