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PURPOSE: This clinical trial studies omega-3 fatty acids in treating patients with advanced prostate cancer.
- To conduct a feasibility study of omega-3 polysaturated fatty acid (PUFA) supplementation in patients with advanced prostate cancer.
- To assess the dose of omega-3 PUFA necessary to achieve an omega-6 to -3 ratio of 1:1 on an individual basis.
- Determine the clinical impact of omega-3 PUFA supplementation on disease progression.
OUTLINE: Patients receive long-term omega-3 polysaturated fatty acids (PUFA).
Patients undergo bone scans, DEXA scans, and blood and adipose sampling at baseline and at 1, 6, and 12 months. Patients also complete a 24-hour food-intake survey at the same time points to monitor dietary omega-6 PUFA intake.
Masking: Open Label, Primary Purpose: Treatment
omega-3 fatty acids, laboratory biomarker analysis, survey administration, bone scan, dual x-ray absorptometry
Not yet recruiting
Wake Forest University
Published on BioPortfolio: 2014-08-27T03:18:35-0400
RATIONALE: Polyunsaturated fatty acids are important for normal growth and development. One type, called omega-3 fatty acids (found in fish, fish oil, and some other foods), may affect the...
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FATTY ACIDS which have the first unsaturated bond in the sixth position from the omega carbon. A typical American diet tends to contain substantially more omega-6 than OMEGA-3 FATTY ACIDS.
A group of fatty acids, often of marine origin, which have the first unsaturated bond in the third position from the omega carbon. These fatty acids are believed to reduce serum triglycerides, prevent insulin resistance, improve lipid profile, prolong bleeding times, reduce platelet counts, and decrease platelet adhesiveness.
A group of fatty acids that contain 18 carbon atoms and a double bond at the omega 9 carbon.
FATTY ACIDS found in the plasma that are complexed with SERUM ALBUMIN for transport. These fatty acids are not in glycerol ester form.
Organic, monobasic acids derived from hydrocarbons by the equivalent of oxidation of a methyl group to an alcohol, aldehyde, and then acid. Fatty acids are saturated and unsaturated (FATTY ACIDS, UNSATURATED). (Grant & Hackh's Chemical Dictionary, 5th ed)
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In a clinical trial or interventional study, participants receive specific interventions according to the research plan or protocol created by the investigators. These interventions may be medical products, such as drugs or devices; procedures; or change...