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A Phase 1 Protocol of 5-Azacytidine and Erlotinib in Advanced Solid Tumor Malignancies

2014-08-27 03:18:39 | BioPortfolio

Summary

Primary Objectives To evaluate the safety and activity of administering a combination of two antineoplastic agents, erlotinib and 5-azacytidine, in an effort to inhibit multiple operative growth factor pathways directly and via epigenetic mechanisms, as therapy for the treatment of advanced or metastatic cancer, as determined by the quality and quantity of adverse events.

Secondary Objectives To evaluate the response to treatment as determined by the achievement of an objective tumor response, progression-free survival and overall survival.

Description

Same as above

Study Design

Allocation: Non-Randomized, Endpoint Classification: Safety Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Advanced Solid Tumor Malignancies

Intervention

5-azacytidine, erlotinib

Location

University of New Mexico Cancer Center
Albuquerque
New Mexico
United States
87106

Status

Recruiting

Source

New Mexico Cancer Care Alliance

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:18:39-0400

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Medical and Biotech [MESH] Definitions

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