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RATIONALE: Studying samples of bone marrow and blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors predict how patients will respond to treatment.
PURPOSE: This research study is looking at bone marrow and blood samples from patients with leukemia or other hematopoietic cancers.
- Determine the frequency and prognostic significance of cytogenetic abnormalities in bone marrow or peripheral blood cells in patients with leukemia prior to treatment and at various times during treatment undergoing treatment on a companion clinical trial.
- Correlate the presence of cytogenetic features with clinical, pathophysiological, cellular, and molecular characteristics in these patients.
- Determine the frequency of trisomy 12 in patients with chronic lymphocytic leukemia (CLL) by fluorescence in situ hybridization (FISH) and conventional cytogenetics.
- Determine the feasibility of FISH as a clinical diagnostic technique in patients with CLL.
- Correlate clinical-pathological prognostic data with the presence of trisomy 12 as detected by FISH and cytogenetics in patients with CLL.
- Develop a cooperative group mechanism to study chromosome abnormalities by FISH in patients with leukemia.
- Provide quality control for all Southwest Oncology Group cytogenetic data.
OUTLINE: Bone marrow and/or peripheral blood samples from patients on specific treatment protocols for leukemia are analyzed for cytogenetic abnormalities. Samples from patients with chronic lymphocytic leukemia (CLL) are analyzed for trisomy 12 by fluorescence in situ hybridization and conventional cytogenetics.
PROJECTED ACCRUAL: Approximately 2,500 patients (1,200 with first-line acute myeloid leukemia [AML], 500 with first-line acute lymphoblastic leukemia [ALL], 200 with relapsed AML, 125 with chronic phase chronic myelogenous leukemia [CML], 100 with accelerated phase or blastic phase CML, 250 with hairy cell leukemia, and 125 with relapsed ALL or CLL) will be accrued for this study within 5 years.
cytogenetic analysis, fluorescence in situ hybridization
Providence Cancer Center at Providence Hospital
National Cancer Institute (NCI)
Published on BioPortfolio: 2014-08-27T03:18:39-0400
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