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The purpose of this clinical investigation is to evaluate acute and longlasting sideeffects at patients undergoing radiotherapy for cancer treatment in the head and neck area.
The so called "Dental Team" at the Department for Oral and Maxillofacial Surgery in Trondheim takes care of patients before, during and also after radiotherapy in the head and neck area. Inspite of the use of advanced radiation protocolls and prevention measures such like fluoridation splints they observe significant sideeffects, both under radiation and also on the long term after concluding treatment. Common problems are for eksample dermal and mucosal damages, reduced salivation,dysphagia and lesions of the teeth. Aim of the study is the investigation and documentation of sideeffects and complications in relation to the oral cavity. During the acute and postradiation phase a continous follow up over a longer lasting period is proceeded with registration of all relevant parameters. This includes among others dental status and evaluation of quality of life.
Observational Model: Cohort, Time Perspective: Prospective
Mucositis of the Oral Mucosa
Department for Oral and Maxillofacial Surgery, St.Olavs Hospital / NTNU
Norwegian University of Science and Technology
Published on BioPortfolio: 2014-08-27T03:18:40-0400
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To evaluate the efficacy, safety, and pharmacokinetics (PK) of liquid cobiprostone in preventing oral mucositis, when administered topically to the oral mucosa via spray for the duration o...
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An INFLAMMATION of the MUCOSA with burning or tingling sensation. It is characterized by atrophy of the squamous EPITHELIUM, vascular damage, inflammatory infiltration, and ulceration. It usually occurs at the mucous lining of the MOUTH, the GASTROINTESTINAL TRACT or the airway due to chemical irritations, CHEMOTHERAPY, or radiation therapy (RADIOTHERAPY).
Lining of the ORAL CAVITY, including mucosa on the GUMS; the PALATE; the LIP; the CHEEK; floor of the mouth; and other structures. The mucosa is generally a nonkeratinized stratified squamous EPITHELIUM covering muscle, bone, or glands but can show varying degree of keratinization at specific locations.
A disorder of the buccal mucosa resembling early leukoplakia, characterized by the presence of filmy opalescence of the mucosa in the early stages to a whitish gray cast with a coarsely wrinkled surface in the later stages, associated with intracellular edema of the spinous or malpighian layer. (Dorland, 27th ed)
Oral lesions accompanying cutaneous lichen planus or often occurring alone. The buccal mucosa, lips, gingivae, floor of the mouth, and palate are usually affected (in a descending order of frequency). Typically, oral lesions consist of radiating white or gray, velvety, threadlike lines, arranged in a reticular pattern, at the intersection of which there may be minute, white, elevated dots or streaks (Wickham's striae). (Jablonski, Illustrated Dictionary of Dentistry)
A white patch seen on the oral mucosa. It is considered a premalignant condition and is often tobacco-induced. When evidence of Epstein-Barr virus is present, the condition is called hairy leukoplakia (LEUKOPLAKIA, HAIRY).
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