Simvastatin in Colonic Surgery

2014-08-27 03:18:40 | BioPortfolio


Statins are the most commonly prescribed class of drugs and inhibit the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase enzyme lowering serum cholesterol and thus reducing cardiovascular risk. New evidence, however, suggests that Statins may also have uses beyond lipid lowering. Statins have shown anti-inflammatory and anti-oxidant properties, they prolong endothelial Nitric Oxide Synthase to act as vasodilators and have systemic influence at the cellular level. Statins have also been shown to decrease peritoneal inflammation and decrease levels of pro-inflammatory cytokines which the investigators have previously shown are correlated to recovery after surgery. Retrospective and Laboratory studies investigating Statins have reported improved outcomes in sepsis and Acute Pancreatitis as well as decreased rates of surgical wound infections and post-operative respiratory complications. They have also been shown to reduce intestinal ischaemia and reperfusion injury decreasing the risk of bacterial translocation and reducing the impact of the Systemic Inflammatory Response Syndrome (SIRS). No prospective studies have evaluated the perioperative use of Simvastatin in Colorectal Surgery or evaluated the impact of Statin use on systemic and local peritoneal cytokine release. The investigators will conduct a case-control study and then a randomized controlled trial (RCT) comparing Simvastatin to placebo to determine whether there are differences in both cytokine response and recovery. No such studies have been previously conducted.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment


Intestinal Neoplasm


Simvastatin, Placebo


Manukau Surgical Centre, Middlemore Hospital
New Zealand


Not yet recruiting


University of Auckland, New Zealand

Results (where available)

View Results


Published on BioPortfolio: 2014-08-27T03:18:40-0400

Clinical Trials [703 Associated Clinical Trials listed on BioPortfolio]

A Research Study to Evaluate MK0653 (Ezetimibe) and Simvastatin, Given Together and Alone, on Intestinal Absorption of Cholesterol (0653-050)(COMPLETED)

To determine the effect of ezetimibe and simvastatin given together, and ezetimibe and simvastatin given alone on intestinal cholesterol absorption.

Ezetimibe and Simvastatin in Primary Hypercholesterolemia, Diabetes Mellitus Type 2, and Coronary Heart Disease (COMPLETED)

This multicenter, randomized, double-blind, placebo-controlled study will assess, after 6 weeks of dosing, whether co-administration of ezetimibe 10 mg with simvastatin 20 mg will be more ...

Safety and Efficacy Study of JTT-705 in Combination With Simvastatin 40 mg in Patients With Low High-Density Lipoprotein (HDL) Levels

The purpose of this study is to evaluate safety of JTT-705 and to demonstrate efficacy of JTT-705 compared with placebo when co-administered with simvastatin 40 mg in patients with low HDL

Ezetimibe Plus Simvastatin Versus Simvastatin in Untreated Subjects With High Cholesterol (P03435)(COMPLETED)

This study will assess whether co-administration of ezetimibe 10 mg with simvastatin 20 mg will be more effective than treatment with simvastatin 20 mg alone in reducing LDL-C concentratio...

Clinical Trial of Simvastatin to Treat Generalized Vitiligo

The investigators purpose is to initiate a phase II, randomized, placebo-controlled clinical trial to test simvastatin, an FDA-approved medication for hypercholesterolemia, as a new treatm...

PubMed Articles [2921 Associated PubMed Articles listed on BioPortfolio]

Simvastatin-induced Changes in the Leukocytic System of Porcine Bone Marrow.

Simvastatin is a substance which is commonly used as a medicine to reduce cholesterol level. Unfortunately, it shows numerous side effects. Simvastatin affects various internal organs, and among other...

Simvastatin-related myopathy in shift workers: a report of two cases.

Background Simvastatin is a widely used drug for dyslipidemia treatment, and the best therapeutic effects are achieved at night time. Simvastatin administration has been associated with the developmen...

Bioanalytical method development and its application to pharmacokinetics studies on Simvastatin in the presence of Piperine and two of its synthetic derivatives.

Piperine has been widely used as a bioenhancer. Simvastatin belongs to a group of medicines known as statins. It acts by inhibiting HMG CoA reductase and acts primarily as a hypolipidemic agent. In th...

The Association between Genetic Polymorphisms and Simvastatin-Induced Myopathy: A Narrative Synthesis of Evidence.

Genetic polymorphisms may play a role in muscular injury associated with simvastatin, but results were inconclusive. This study aimed to summarize evidence from the literature investigating the effect...

Positive influence of simvastatin used as adjuvant agent for cavity lining.

To assess the biological, antimicrobial, and mechanical effects of the treatment of deep dentin with simvastatin (SV) before application of a glass-ionomer cement (GIC).

Medical and Biotech [MESH] Definitions

A pharmaceutical preparation of ezetimibe and simvastatin that is used in the treatment of HYPERCHOLESTEROLEMIA and HYPERLIPIDEMIAS.

Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause.

A condition caused by the lack of intestinal PERISTALSIS or INTESTINAL MOTILITY without any mechanical obstruction. This interference of the flow of INTESTINAL CONTENTS often leads to INTESTINAL OBSTRUCTION. Ileus may be classified into postoperative, inflammatory, metabolic, neurogenic, and drug-induced.

Misunderstanding among individuals, frequently research subjects, of scientific methods such as randomization and placebo controls.

Dilatation of the intestinal lymphatic system usually caused by an obstruction in the intestinal wall. It may be congenital or acquired and is characterized by DIARRHEA; HYPOPROTEINEMIA; peripheral and/or abdominal EDEMA; and PROTEIN-LOSING ENTEROPATHIES.

More From BioPortfolio on "Simvastatin in Colonic Surgery"

Quick Search


Relevant Topics

Enzymes are proteins that catalyze (i.e., increase the rates of) chemical reactions. In enzymatic reactions, the molecules at the beginning of the process, called substrates, are converted into different molecules, called products. Almost all chemical re...

Cardiology is a specialty of internal medicine.  Cardiac electrophysiology : Study of the electrical properties and conduction diseases of the heart. Echocardiography : The use of ultrasound to study the mechanical function/physics of the h...

Searches Linking to this Trial