N-Acetylcysteine for Pediatric Trichotillomania

2014-08-27 03:18:45 | BioPortfolio


Trichotillomania (hair pulling) has an estimated lifetime prevalence of 1-3%. Children with trichotillomania can experience significant impairment due to peer teasing, avoidance of activities (such as swimming and socializing), difficulty concentrating on school work and medical complications due to pulling behaviors. Despite the fact that trichotillomania has a childhood onset, no randomized, controlled trials have been completed in childhood trichotillomania.

Research in adults with trichotillomania has demonstrated that most commonly currently prescribed treatment for trichotillomania, (pharmacotherapy with selective serotonin reuptake inhibitors) is ineffective in treating this condition. By contrast, randomized controlled trials in adults have suggested the efficacy of N-acetylcysteine as well as behavioral treatments such as Habit Reversal Therapy.

The goal of this trial is to determine the efficacy of N-Acetylcysteine for pediatric trichotillomania. N-Acetylcysteine is a glutamate modulating agent, with a fairly benign side-effect profile.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment




N-Acetylcysteine, Placebo


Yale Child Study Center
New Haven
United States




Yale University

Results (where available)

View Results


Published on BioPortfolio: 2014-08-27T03:18:45-0400

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PubMed Articles [867 Associated PubMed Articles listed on BioPortfolio]

N-Acetylcysteine in Psychodermatological disorders.

Treatment of psychodermatological conditions, particularly body focused repetitive behavior disorders, is often unsatisfactory. Various psychopharmacological and non-pharmacological treatments have be...

Duration of illness and cortical thickness in trichotillomania: Preliminary evidence for illness change over time.

Trichotillomania is a psychiatric condition characterized by repetitive pulling out of one's hair, leading to marked functional impairment. The aim of this study was to examine the association between...

N-Acetylcysteine for Pediatric Obsessive-Compulsive Disorder: A Small Pilot Study.

Many children and adults with Obsessive-Compulsive Disorder (OCD) fail to respond to first-line pharmacological and behavioral treatments. Glutamate dysfunction may contribute to the development of OC...

Trichotillomania comorbidity in a sample enriched for familial obsessive-compulsive disorder.

This study addresses the strength of associations between trichotillomania (TTM) and other DSM-IV Axis I conditions in a large sample (n = 2606) enriched for familial obsessive-compulsive disorder...

A latent profile analysis of age of onset in trichotillomania.

Trichotillomania (TTM) onset may occur across the lifespan; however, adolescent onset is most frequently reported. Several studies have explored clinical differences between TTM age-of-onset groups wi...

Medical and Biotech [MESH] Definitions

Compulsion to pull out one's hair.

Misunderstanding among individuals, frequently research subjects, of scientific methods such as randomization and placebo controls.

The N-acetyl derivative of CYSTEINE. It is used as a mucolytic agent to reduce the viscosity of mucous secretions. It has also been shown to have antiviral effects in patients with HIV due to inhibition of viral stimulation by reactive oxygen intermediates.

An effect usually, but not necessarily, beneficial that is attributable to an expectation that the regimen will have an effect, i.e., the effect is due to the power of suggestion.

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