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Mechanisms Defending Fat Mass in Humans After Lipectomy

2014-08-27 03:18:45 | BioPortfolio

Summary

Liposuction surgery is common, yet animal and limited human data suggest that fat returns when removed. We undertook a 1-year randomized-controlled trial of suction lipectomy versus no intervention to determine if adipose tissue is defended, and if so to determine the anatomic pattern of redistribution.

Description

Specific Aims:

1. To determine if suction lipectomy fails to modify regional and/or total body fat over three years.

2. To determine if the expression of candidate genes predicts and/or relates to subcutaneous adipose tissue growth or depletion in subcutaneous adipose tissue after suction lipectomy.

3. To examine adipose tissue before and after suction lipectomy to uncover novel genes where expression predicts and/or relates to subcutaneous adipose tissue growth or depletion after subcutaneous suction lipectomy.

Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Disproportionate Shape Created by Expanded Fat Pads.

Intervention

Liposuction

Location

University of Colorado Denver
Aurora
Colorado
United States
80045

Status

Completed

Source

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:18:45-0400

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