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To Compare Positron Emission Tomography (PET) Measurements of Fibrillar Amyloid Burden

2014-08-27 03:18:47 | BioPortfolio

Summary

The purpose of this study is to compare PET measurements of fibrillar amyloid burden using [18F]AZD4694.

Study Design

Allocation: Non-Randomized, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic

Conditions

Alzheimer's Disease

Intervention

[18F]AZD4694

Location

Research Site
Phoenix
Arizona
United States

Status

Recruiting

Source

AstraZeneca

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:18:47-0400

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Medical and Biotech [MESH] Definitions

Abnormal structures located chiefly in distal dendrites and, along with NEUROFIBRILLARY TANGLES and SENILE PLAQUES, constitute the three morphological hallmarks of ALZHEIMER DISEASE. Neuropil threads are made up of straight and paired helical filaments which consist of abnormally phosphorylated microtubule-associated tau proteins. It has been suggested that the threads have a major role in the cognitive impairment seen in Alzheimer disease.

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