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Muscle Characteristics Associated With Statin Therapy

2014-07-24 14:11:18 | BioPortfolio

Summary

The purpose of this study is to investigate the mechanism of statin-related myopathy by evaluating muscle samples before and after statin exposure.

Description

Statins have been proven to reduce cardiovascular events and mortality in large clinical trials but remain underutilized partly due to the associated myopathy. Severe reactions manifested as rhabdomyolysis are rare but myalgia is commonly noted in clinical practice. The pathophysiology of these events remains obscure. Previous studies suggest that statins block the downstream products (such as cellular signaling molecules) of the mevalonate pathway needed for normal muscle function. Other studies show that statins are associated with gene expressions involved in muscle damage such as atrogin-1. We will quantify these entities pre and post statin therapy to better understand these reactions.

Study Design

Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science

Conditions

Hydroxymethylglutaryl-CoA Reductase Inhibitors

Intervention

simvastatin

Location

Scripps-Mercy Hospital
San Diego
California
United States
92103

Status

Not yet recruiting

Source

Scripps Health

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-07-24T14:11:18-0400

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