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A Study to Investigate the Safety and Tolerability of MK-0517 in Healthy Subjects (MK-0517-012)

2014-12-05 09:52:30 | BioPortfolio

Published on BioPortfolio: 2014-12-05T09:52:30-0500

Clinical Trials [250 Associated Clinical Trials listed on BioPortfolio]

Efficacy and Safety Study of Fosaprepitant (MK-0517) Plus Ondandsetron Versus Ondansetron Alone for the Prevention of Chemotherapy-Induced Nausea and Vomiting in Pediatric Participants (MK-0517-044)

The purpose of this study is to evaluate the efficacy and safety of fosaprepitant (MK-0517) plus ondansetron versus ondansetron alone for the prevention of chemotherapy-induced nausea and ...

Study of the Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Fosaprepitant for the Prevention of Chemotherapy-Induced Nausea and Vomiting (CINV) in Children (MK-0517-029)

The purpose of this study is to determine the appropriate dosing regimen of fosaprepitant, when administered with ondansetron (with or without dexamethasone), for the prevention of CINV in...

Efficacy and Safety of Fosaprepitant Dimeglumine in Preventing Chemotherapy-Induced Nausea and Vomiting (MK-0517-031)

This study aims to demonstrate that, when given concomitantly with a 5-hydroxytryptamine 3 (5-HT3) antagonist and a corticosteroid, a single 150 mg intravenous (IV) dose of fosaprepitant g...

CP-690,550 and Midazolam Drug-Drug Interaction Study

CP-690,550 and midazolam are metabolized by similar enzymes in the liver. This study is designed to assess whether co-administration of CP-690,500 and midazolam will effect the metabolism ...

Intranasal Midazolam in Children as a Pre-Operative Sedative

The purpose of this study is to see if adding a numbing medicine, xylocaine, to the nasal midazolam makes giving the midazolam easier and more comfortable without affecting how the midazol...

PubMed Articles [51 Associated PubMed Articles listed on BioPortfolio]

A newly identified impurity in Polysorbate 80, the long-chain ketone 12-tricosanone, forms visible particles in a biopharmaceutical drug product.

Visible particles linked to polysorbates used in biopharmaceutical drug products have been observed repeatedly in recent years as an industry-wide issue, with polysorbate degradation and insoluble deg...

Microstructural distinction of electrospun nanofibrous drug delivery systems formulated with different excipients.

The electrospun nanofiber-based orally dissolving webs are promising candidates for rapid drug release, which is due to the high surface area to volume ratio of the fibers and the high amorphization e...

Preparation and Evaluation of Midazolam Rectal Gel in vitro and in vivo.

Midazolam has been successfully used for sedation, which the tablets, injections and oral solutions were available in market. However, the oral bioavailability of midazolam is less due to the first ef...

The apoptotic effect of Midazolam on the salivary gland of rats and the reversal effect by Pilocarpine.

To evaluated the apoptosis in parotid glands of rats treated with Midazolam associated or not with Pilocarpine, Sixty Wistar rats were assigned to 6 groups: control group received saline solution for ...

Midazolam is effective to reduce cortical network activity in organotypic cultures during severe cholinergic overstimulation with soman.

Intoxication with organophosphorus compounds can result in life-threatening organ dysfunction and refractory seizures. Sedation or hypnosis is essential to facilitate mechanical ventilation and contro...

Medical and Biotech [MESH] Definitions

A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.

A cytochrome P-450 monooxygenase that is involved in an NADPH-dependent electron transport pathway by oxidizing a variety of structurally unrelated compounds, including STEROIDS; FATTY ACIDS; and XENOBIOTICS. This enzyme has clinical significance due to its ability to metabolize a diverse array of clinically important drugs such as CYCLOSPORINE; VERAPAMIL; and MIDAZOLAM. This enzyme also catalyzes the N-demethylation of ERYTHROMYCIN.

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