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Study of Plerixafor Combined With Cytarabine and Daunorubicin in Patients With De Novo Acute Myeloid Leukemia

2014-08-27 03:18:52 | BioPortfolio

Summary

The purpose of this research study is to determine if Plerixafor can release cells into the blood and make them more sensitive to killing by Cytarabine and Daunorubicin, an anti-cancer drug regimen referred to as "7+3" that is commonly used in treating acute myeloid leukemia (AML). In this study, Plerixafor will be added to treatment with Cytarabine and Daunorubicin. Subjects will be monitored to see how well they tolerate the use of these drugs together and how well they work to treat the leukemia.

The study is divided into Part 1 and Part 2. The purpose of Part 1 of the study is to find the highest dose of Plerixafor that can be given safely with Cytarabine and Daunorubicin. The purpose of Part 2 of the study is to collect additional safety information for Plerixafor when used with Cytarabine and Daunorubicin to see the effects the combination treatment has on the subject and his/her leukemia.

Study Design

Allocation: Non-Randomized, Endpoint Classification: Safety Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

De Novo Acute Myeloid Leukemia

Intervention

Plerixafor

Location

Duarte
California
United States

Status

Recruiting

Source

Genzyme

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:18:52-0400

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