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Perineuraxial Anesthesia Fluid Management and Infant Neurobehaviors

2014-07-24 14:11:20 | BioPortfolio

Summary

Early change in neurobehavior is strongly associated with the intelligence development of children. Previous studies reported that cesarean section itself could influence the later development of children. In addition, neuraxial anesthesia including epidural, spinal and combined spinal epidural anesthesia (CSEA) are the major forms used during cesarean delivery, and these anesthesia techniques will undoubtedly evoke hypotension and corresponding hemodynamic alteration, of which would result in decreasing in umbilical placental insufficiency and fetus hypoxia leading to early abnormality of neurobehaviors in infants. Fluid management, such as crystalloid and colloid, is the common ones given before or / and after neuraxial anesthesia to prevent or reverse hypotension. However, it is still unknown whether the perineuraxial anesthesia fluid resuscitation could improve the neurobehavior scorings, and could produce positive effect on later intelligence development. Herein the investigators hypothesized that effective perineuraxial anesthesia fluid management during cesarean section would prevent the occurrence of hypotension and improve infant's neurobehavior scorings.

Study Design

Allocation: Randomized, Control: Active Control, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment

Conditions

Cesarean Section

Intervention

Ringer's Lactate, Six percent hydroxyethyl starch

Location

The Affiliated Nanjing Maternity and Child Health Care Hospital
Nanjing
Jiangsu
China
210004

Status

Recruiting

Source

Nanjing Medical University

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-07-24T14:11:20-0400

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Medical and Biotech [MESH] Definitions

Extraction of the fetus by abdominal hysterotomy anytime following a previous cesarean.

Delivery of an infant through the vagina in a female who has had a prior cesarean section.

Starches that have been chemically modified so that a percentage of OH groups are substituted with 2-hydroxyethyl ether groups.

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A cytochrome form of lactate dehydrogenase found in the MITOCHONDRIA. It catalyzes the oxidation of L-lactate to PYRUVATE with transfer of electrons to CYTOCHROME C. The enzyme utilizes FMN and PROTOHEME IX as cofactors.

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