Study on the Efficacy of LAS41005 in the Treatment of Actinic Keratosis

2014-08-27 03:18:58 | BioPortfolio


The purpose of this study is to investigate the efficacy of LAS41005 in comparison to placebo and to LAS106521 in actinic keratosis (AK).


To investigate as primary objective:

- Superiority to placebo and non-inferiority to LAS106521 measured by histological clearance of one predefined target lesion;

To investigate as secondary objective:

- Superiority to LAS106521

- Improvement of treated lesions (lesion response)

- Assessment of tolerability and safety by physicians global assessment score (PGA, PGT)

- Patient's assessment of tolerability and efficacy and patient's compliance

Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment


Actinic Keratosis


Placebo Gel, LAS41005, LAS106521




Almirall, S.A.

Results (where available)

View Results


Published on BioPortfolio: 2014-08-27T03:18:58-0400

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PubMed Articles [963 Associated PubMed Articles listed on BioPortfolio]

Use and Cost of Actinic Keratosis Destruction in the Medicare Part B Fee-for-Service Population, 2007 to 2015.

Actinic keratosis is prevalent and has the potential to progress to keratinocyte carcinoma. Changes in the use and costs of actinic keratosis treatment are not well understood in the aging population.

Claudin-1 expression decreases with increasing pathological grade in actinic keratosis and may be a marker of high-risk actinic keratosis.

Actinic keratosis (AK) is a common sun-induced skin disorder that can progress to invasive squamous cell carcinoma. However, there is still no reliable method to predict high-risk AK.

Validity and Reliability of the Dutch Adaptation of the Actinic Keratosis Quality of Life Questionnaire (AKQoL).

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Diclofenac Sodium 3% in Hyaluronic Acid 2.5% Gel Significantly Diminishes the Actinic Keratosis Area and Severity Index.

Actinic keratosis area and severity index (AKASI) is a new assessment tool to quantify the severity of actinic damage on the head. Thus far, it has not been evaluated in monitoring the efficacy of fie...

Laser-assisted photodynamic therapy for actinic keratosis: A systematic review and meta-analysis.

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Medical and Biotech [MESH] Definitions

A compound produced from succinyl-CoA and GLYCINE as an intermediate in heme synthesis. It is used as a PHOTOCHEMOTHERAPY for actinic KERATOSIS.

White or pink lesions on the arms, hands, face, or scalp that arise from sun-induced DNA DAMAGE to KERATINOCYTES in exposed areas. They are considered precursor lesions to superficial SQUAMOUS CELL CARCINOMA.

Misunderstanding among individuals, frequently research subjects, of scientific methods such as randomization and placebo controls.

Any horny growth such as a wart or callus.

An effect usually, but not necessarily, beneficial that is attributable to an expectation that the regimen will have an effect, i.e., the effect is due to the power of suggestion.

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