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Docosahexaenoic Acid (DHA) Nutritional Supplementation to Prevent Age-related Macular Degeneration (AMD)

2014-08-27 03:18:58 | BioPortfolio

Summary

Docosahexaenoic acid (DHA) supplementation has been shown to prevent specific age-related changes in the retina through biochemical and functional evaluations, but it is unclear how DHA supplementation affects the natural history of age-related macular degeneration (AMD). AMD is a disease affecting the macula, the part of the eye containing cone photoreceptors at the center of the visual field. The macula is responsible for vision in most daily functions, including reading, seeing fine details, and colour recognition. Severe AMD can lead to a central scotoma, severely impairing daily functioning. AMD can be divided into two forms: the more severe wet AMD, consisting of proliferation of new blood vessels in the retina, and dry AMD characterized by the development of drusen, a buildup of extracellular material . We are targeting the group with the highest risk of developing wet AMD: patients with unilateral wet AMD and dry AMD in their other eye. The study will consist of supplementing subjects with commercially available DHA supplements and monitoring their visual function in a comprehensive manner. Working in concert with clinical ophthalmologists and basic scientists, we will monitor DHA levels in the blood, inherited predispositions through genetic analysis, lipofuscin (an accumulated waste product) levels & AMD progression via fundus photography, visual acuity, and retinal function via full-field and multifocal electroretinograms. These different factors will be cross-correlated and evaluated to determine how DHA supplementation affects the development of AMD.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Prevention

Conditions

Age-Related Macular Degeneration

Intervention

Ocean Nutrition MEG3 4020EE product, Flax seed oil capsule

Location

Alberta Retina Consultants
Edmonton
Alberta
Canada
T5H 0X5

Status

Not yet recruiting

Source

University of Alberta

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:18:58-0400

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Ophthalmology
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