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The purpose of this study is to test:
1. Safety of 900 mg or 1800 mg of WS® 1442 per day in overweight subjects (BMI 25 to 29,9 kg/m²)
2. Pharmacodynamic effect of WS® 1442 on endothelial function versus nordic walking training in overweight subjects
60 overweight subjects with a BMI of 25 to 29,9 kg/m2 are to be included. The safety of 900 mg/1800 mg per day WS® 1442 is determined by adverse events, laboratory parameters, vital signs as well as by a treadmill test at the beginning and the end of the study. Endothelial function measured before and after two different training modalities is compared to that measured before and after intake of two different doses of WS® 1442.
Allocation: Randomized, Control: Active Control, Endpoint Classification: Safety Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator)
WS® 1442 900 mg/d, WS® 1442 1800 mg/d, Nordic walking training 2 x 30 min/week, Nordic walking training 4x45 min/week
University Institute of Sports Medicine, Prevention and Rehabilitation, Paracelsus Medical University Salzburg
Dr. Willmar Schwabe GmbH & Co. KG
Published on BioPortfolio: 2014-07-23T21:12:42-0400
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An activity in which the body advances at a slow to moderate pace by moving the feet in a coordinated fashion. This includes recreational walking, walking for fitness, and competitive race-walking.
The rate at which steps are made while walking.
Financial support for training including both student stipends and loans and training grants to institutions.
Time period from 1701 through 1800 of the common era.
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