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An Efficacy and Safety Trial of Intravenous Zoledronic Acid in Infants Less Than One Year of Age, With Severe Osteogenesis Imperfecta

2014-07-23 21:12:42 | BioPortfolio

Summary

The investigators have currently finished conducting an international multi-center trial that compares the efficacy and safety of pamidronate and zoledronate in the treatment of moderate to severe forms of Osteogenesis Imperfecta (OI). This trial has included only children above one year of age. The aim of the current study is to extend the observations of that currently finished study to infants below 1 year of age. Moreover, it is possible to administer zoledronate in a single short infusion instead of the three-day cycles with Pamidronate, therefore decreasing patient and family burdens with shorter stays in the hospital.

Study Design

Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Supportive Care

Conditions

Osteogenesis Imperfecta

Intervention

Zoledronic Acid

Location

Shriners Hospital for Children
Montreal
Quebec
Canada
H3G 1A6

Status

Recruiting

Source

Shriners Hospitals for Children

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-07-23T21:12:42-0400

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Medical and Biotech [MESH] Definitions

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The process of bone formation. Histogenesis of bone including ossification.

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