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Aldosterone Blockade to Prevent Myocardial Remodeling In Patients With Controlled Essential Hypertension

2014-08-27 03:19:13 | BioPortfolio

Summary

The goal of this project is to investigate the effects that the addition of aldosterone blockade with eplerenone will have on the progression of diastolic dysfunction in patients with controlled essential hypertension.

Description

The purpose of this project is to determine if eplerenone, an aldosterone blocker, prevents remodelling of the heart in patients with controlled essential hypertension, defined as having a blood pressure of equal to or less than 130/80 in diabetics and equal to or less than 140/90 in non-diabetics. This study will investigate if the addition of 25 milligrams of eplerenone daily to a subject's hypertension medication regimen will prevent the progression or development of diastolic dysfunction. Echocardiography will be used to measure the changes in heart structure of subjects receiving eplerenone versus subjects receiving placebo (a drug that may resemble the study drug but contains no active ingredient). Approximately 30 subjects will take part in this study.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Prevention

Conditions

Myocardial Remodeling

Intervention

Eplerenone, Lactose Tablet

Location

Creighton University Medical Center (including ambulatory centers)
Omaha
Nebraska
United States
68131

Status

Recruiting

Source

Creighton University

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:19:13-0400

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