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The Effect of Uric Acid Decrement on Endothelial Function in Patients With Chronic Renal Failure

2014-08-27 03:19:17 | BioPortfolio

Summary

In this prospective study, the investigators aimed to evaluate the effects of improved hyperuricemia, a minor cardiovascular risk factor, on endothelial dysfunction in patients with chronic kidney disease.

Description

Endothelial dysfunction (ED) is a key event in the development of atherosclerotic cardiovascular disease observed in patients with chronic kidney disease (CKD). Experimental models have shown that hyperuricemia causes hypertension and renin angiotensin system activation. In this prospective study, the investigators aimed to evaluate the effects of improved hyperuricemia, a minor cardiovascular risk factor, on ED in patients with CKD.

Study Design

Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Screening

Conditions

Hyperuricemia

Intervention

allopurinol

Location

Istanbul Faculty of Medicine
Istanbul
Turkey
34390

Status

Completed

Source

Istanbul University

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:19:17-0400

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Medical and Biotech [MESH] Definitions

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A syndrome resulting from cytotoxic therapy, occurring generally in aggressive, rapidly proliferating lymphoproliferative disorders. It is characterized by combinations of hyperuricemia, lactic acidosis, hyperkalemia, hyperphosphatemia and hypocalcemia.

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