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Study of Prostate Samples in Predicting Cancer Recurrence in Patients With Prostate Cancer

2014-08-27 03:19:19 | BioPortfolio

Summary

RATIONALE: Studying prostate samples from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors predict how patients will respond to treatment.

PURPOSE: This phase I trial is studying prostate samples in predicting cancer recurrence in patients with prostate cancer.

Description

OBJECTIVES:

- Develop a data model (nomogram) that incorporates patient age, biopsy, Gleason score, and a molecular profile incorporating promoter methylation status at selected genes and RNA expression from the hTERT component of telomerase.

- Explore the performance of this model in predicting the likelihood of biochemical recurrence.

- Describe the performance and Gleason score determined on resected prostate specimens.

OUTLINE: Patients undergo expressed prostatic secretion sample collection before robotic-assisted prostatectomy for biomarker analysis.

Study Design

N/A

Conditions

Prostate Cancer

Intervention

DNA analysis, DNA methylation analysis, RNA analysis, gene expression analysis, polymerase chain reaction, laboratory biomarker analysis

Location

City of Hope Comprehensive Cancer Center
Duarte
California
United States
91010-3000

Status

Recruiting

Source

National Cancer Institute (NCI)

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:19:19-0400

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