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Postprandial Inflammation and Fatty Acids

2014-08-27 03:19:19 | BioPortfolio

Summary

The main objective is to elucidate the acute effects of an oral intake of either saturated, monounsaturated or polyunsaturated fatty acids on peripheral blood mononuclear cells (PBMC) whole genome expression of obese and type 2 diabetic obese subjects.

Description

Consumption of high-fat diets can lead to postprandial dyslipidemia, impairment of endothelial function, activation of immune cells and changes in gene expression profiles of immune cells such as peripheral blood mononuclear cells (PBMC). Recently it was shown that postprandial gene expression profiles of PBMC and plasma triglyceride (TG) and free fatty acid (FFA) responses are dependent on the type of dietary fat consumed (i.e. saturated, monounsaturated and polyunsaturated). Since obese and diabetic subjects usually are in a pro-inflammatory state and have dyslipidemia and endothelial dysfunction we are interested in the effect of different fatty acids in a high load on the PBMC gene expression profiles, plasma cytokine profiles and endothelial function of these subjects.

Study Design

Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator)

Conditions

Cardiovascular Disease

Intervention

High saturated fat shake, High monounsaturated fat shake, High polyunsaturated fat shake

Location

Wageningen University, Division of Human Nutrition
Wageningen
Gelderland
Netherlands
6700 EV

Status

Completed

Source

Wageningen University

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:19:19-0400

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