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Triggering receptor expressed on myeloid cells (TREM)-1 is a recently described molecule that plays an important role in myeloid cell-activated inflammatory responses. The aim of this study was to investigate the evolutional change of soluble TREM-1 (sTREM-1) in bronchoalveolar lavage (BAL) fluid of clinically diagnosed ventilator-associated pneumonia (VAP) and its correlation with response to treatment and outcome.
A prospective, interventional study conducted between August 2006 and August 2007 in MICU in Mackay Memorial Hospital, 35 patients with clinically diagnosed VAP were investigated. sTREM-1 was measured in BAL samples using ELISA at the onset, 4th - 5th and 7th - 9th day of clinical diagnosis of VAP.Of these 35 patients, 27 had positive BAL culture. The sTREM-1 levels in BAL fluid were measured and compared between patients with positive BAL culture and negative BAL culture. Serial changes in sTREM-1 levels were evaluated in relation to patient outcome.
Observational Model: Case-Only, Time Perspective: Prospective
Mackay Memorial Hospital
Mackay Memorial Hospital
Published on BioPortfolio: 2014-07-24T14:11:34-0400
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Pneumonia due to aspiration or inhalation of various oily or fatty substances.
A species of the genus PNEUMOVIRUS causing pneumonia in mice.
Severe complication of pneumonia characterized by liquefaction of lung tissue.
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