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Serial Changes in sTREM-1 During Ventilator-associated Pneumonia (VAP)

2014-07-24 14:11:34 | BioPortfolio

Summary

Triggering receptor expressed on myeloid cells (TREM)-1 is a recently described molecule that plays an important role in myeloid cell-activated inflammatory responses. The aim of this study was to investigate the evolutional change of soluble TREM-1 (sTREM-1) in bronchoalveolar lavage (BAL) fluid of clinically diagnosed ventilator-associated pneumonia (VAP) and its correlation with response to treatment and outcome.

Description

A prospective, interventional study conducted between August 2006 and August 2007 in MICU in Mackay Memorial Hospital, 35 patients with clinically diagnosed VAP were investigated. sTREM-1 was measured in BAL samples using ELISA at the onset, 4th - 5th and 7th - 9th day of clinical diagnosis of VAP.Of these 35 patients, 27 had positive BAL culture. The sTREM-1 levels in BAL fluid were measured and compared between patients with positive BAL culture and negative BAL culture. Serial changes in sTREM-1 levels were evaluated in relation to patient outcome.

Study Design

Observational Model: Case-Only, Time Perspective: Prospective

Conditions

Pneumonia

Intervention

Bronchoscopy BAL

Location

Mackay Memorial Hospital
Taipei
Taiwan
106

Status

Completed

Source

Mackay Memorial Hospital

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-07-24T14:11:34-0400

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Medical and Biotech [MESH] Definitions

Endoscopic examination, therapy or surgery of the bronchi.

Pneumonia caused by infection with bacteria of the family RICKETTSIACEAE.

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A species of the genus PNEUMOVIRUS causing pneumonia in mice.

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