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New Acute Treatment for Stroke - The Effect of Remote PERconditioning

2014-08-27 03:19:24 | BioPortfolio

Summary

This study is a blinded randomized study. Randomization for treatment/not treatment with remote perconditioning takes place during transportation to the hospital. This is because the investigators' hypothesis states that remote perconditioning is neuro-protective and the effect is proportionally larger with early treatment. As the size of the effect is unknown, the investigators will use multiple magnetic resonance imaging (MRI) scans to determine the size of a potential neuro-protective effect.

The aims of this study are:

1. To describe method of remote perconditioning in clinical practice regarding feasibility. Pros and cons and potential limitations.

2. To estimate the size of the effect of remote perconditioning in combination with recombinant tissue plasminogen activator (rtPa) treatment within four and a half hours of onset of symptoms.

Description

Final inclusion and informed consent takes place after first MRI in patients eligible for rtPA.

Follow-up MRI after 24h and 1 month. Clinical outcome at 3 months.

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Investigator, Outcomes Assessor), Primary Purpose: Treatment

Conditions

Acute Stroke

Intervention

Remote preconditioning

Location

Department of Neurology, Aarhus University Hospital
Aarhus
Denmark
8000

Status

Recruiting

Source

Aarhus University Hospital

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:19:24-0400

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Medical and Biotech [MESH] Definitions

Consultation via remote telecommunications, generally for the purpose of diagnosis or treatment of a patient at a site remote from the patient or primary physician.

Restoration of functions to the maximum degree possible in a person or persons suffering from a stroke.

Sudden death from overwork, most often as a result of acute CARDIOVASCULAR STROKE.

Stroke caused by lacunar infarction or other small vessel diseases of the brain. It features hemiparesis (see PARESIS), hemisensory, or hemisensory motor loss.

An optical disk storage system used on specialized players that combine the functions of computer and CD player in a self-contained box, designed to be connected to a television set and a home stereo for video and sound output. The player is controlled with a hand-held remote unit resembling a television remote control. (J Allied Health 1993 Winter;22(1):131-8)

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