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The Early Medication Change (EMC) Trial

2014-08-27 03:19:26 | BioPortfolio

Summary

The EMC trial investigates for the first time prospectively whether Major Depression Disorder patients with non-improvement after 14 days of antidepressive treatment with EMC are more likely to become remitters compared to patients treated according to current guidelines, i.e., with a medication change after 28 days of treatment in case of non-response.

Study Design

Allocation: Randomized, Control: Active Control, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Depression

Intervention

Escitalopram, venlafaxine, lithium, Escitalopram, venlafaxine

Location

University Medical Center of the Johannes Gutenberg-University
Mainz
Rheiland Pfalz
Germany
55130

Status

Recruiting

Source

Johannes Gutenberg University Mainz

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:19:26-0400

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Medical and Biotech [MESH] Definitions

A cyclohexanol and phenylethylamine derivative that functions as a SEROTONIN AND NORADRENALINE REUPTAKE INHIBITOR (SNRI) and is used as an ANTIDEPRESSIVE AGENT.

A cyclohexanol and phenol derivative and metabolite of venlafaxine that functions as a SEROTONIN AND NORADRENALINE REUPTAKE INHIBITOR (SNRI) and is used as an ANTIDEPRESSIVE AGENT.

A lithium salt, classified as a mood-stabilizing agent. Lithium ion alters the metabolism of BIOGENIC MONOAMINES in the CENTRAL NERVOUS SYSTEM, and affects multiple neurotransmission systems.

A salt of lithium that has been used experimentally as an immunomodulator.

Inorganic compounds that contain lithium as an integral part of the molecule.

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