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Curcumin in Preventing Colorectal Cancer in Patients Undergoing Colorectal Endoscopy or Colorectal Surgery

2014-08-27 03:19:29 | BioPortfolio

Summary

RATIONALE: Chemoprevention is the use of certain drugs to keep cancer from forming. The use of curcumin may prevent or treat colorectal cancer.

PURPOSE: This phase I trial is studying the side effects of curcumin in preventing colorectal cancer in patients undergoing colorectal endoscopy or colorectal surgery.

Description

OBJECTIVES:

Primary

- To determine levels of curcumin and its metabolites in normal colorectal tissue in patients undergoing colorectal endoscopy or colorectal cancer surgery following a 14-day course of curcumin.

Secondary

- To assess the practicality, acceptability, and safety of administering 5 capsules of curcumin daily for 14 days.

- To check the presence of curcumin and its metabolites in peripheral blood and urine.

OUTLINE: Patients receive oral curcumin once daily for 14-28 days. Patients then undergo colorectal endoscopy or resection.

Normal colorectal tissue samples are collected via biopsy for curcumin assay after the last dose of curcumin. Patients also undergo blood and urine sample collection at baseline and after the last dose of curcumin for pharmacokinetic analysis by high performance liquid chromatography.

After completion of study treatment, patients are followed up at 14 days.

Study Design

Primary Purpose: Prevention

Conditions

Colorectal Cancer

Intervention

curcumin, high performance liquid chromatography, laboratory biomarker analysis, pharmacological study, diagnostic endoscopic procedure, therapeutic conventional surgery

Location

St. Mark's Hospital
Harrow
England
United Kingdom
HA1 3UJ

Status

Recruiting

Source

National Cancer Institute (NCI)

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:19:29-0400

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