Factors Influencing Cardiovascular Prognosis

2014-08-27 03:19:30 | BioPortfolio


The purpose of this study is to identify risks for cardiovascular events in a follow up period of 10 years.


Inclusion criteria

- Age > 50 years volunteers (2 towns of 15000 residents one in the north and one in the south of Greece)

- End points

- 5-10 years cardiovascular morbidity and mortality

Measurements at baseline

- Anthropometrics

- Age (M>55 years; W>65 years)

- Weight-height- BMI

- Abdominal obesity (Waist circumference>102 cm(M), >88cm (W) Family history

- Family history of premature CV disease (M at age<55 years; W at age<65 years)


- Smoking

- Diabetes Mellitus,

- Established Heart disease: myocardial infarction; angina; coronary revascularization; heart failure

- Established renal disease [diabetic nephropathy; renal impairment (serum creatinine M>133, W>124 mmol/l); proteinuria (> 300 mg/24 h)]

- Cerebrovascular disease: ischaemic stroke; cerebral haemorrhage; transient ischaemic attack

- Peripheral artery disease

- Advanced retinopathy: haemorrhages or exudates, papilloedema

- Treatment


- Measurements Blood pressure

- Clinic BP

- 24h ABPM

- Home BP


- Electrocardiographic LVH

- Echocardiographic LVH


- Carotid wall thickening or plaque

- Carotid-femoral pulse wave velocity

- Ankle/brachial BP index

Lipids or other risk factors

- Total cholesterol, Tg, HDL, LDL

- Plasma creatinine, estimated glomerular filtration rate

- Fasting plasma glucose or postload plasma glucose

- Microalbuminuria and albumin-creatinine ratio

- Glucose tolerance test

- Follow up each 3 year with all the above measurements

Study Design

Observational Model: Cohort, Time Perspective: Prospective


Cardiovascular Mortality


Not yet recruiting


Aristotle University Of Thessaloniki

Results (where available)

View Results


Published on BioPortfolio: 2014-08-27T03:19:30-0400

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