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Iron Overload and Growth Velocity in Thalassemia and Sickle Cell Anemia

2014-08-27 03:19:31 | BioPortfolio

Summary

Iron overload impaired growth in Thalassemia patients due to iron deposition in the endocrine glands, including the hypophysis and gonads. The issue of iron overload in Sickle Cell Anemia is recently studied more extensively and preliminary studies shows that endocrine damage is rarer in those patients.

Growth velocity was not systematically studied in patients with Iron Overload, even in thalassemia patients in spite several studies that assess the endocrine function in those patients. In Sickle Cell Patients this issue was not studied.

The purpose of this study is to assess the growth velocity in a cohort of Thalassemia Major and Intermedia patients and compare the results to another group of Sickle Cell patients, including Sickle cell thalassemia.

Description

Growth velocity, endocrine function and iron overload status will be studied in the patients that are in follow up at the Pediatric Hematology Unit, at the Ha'Emek Medical Center.

Patients who were lost from follow up or insufficient data about growth in the past will not included in the study.

Study Design

Observational Model: Cohort, Time Perspective: Retrospective

Conditions

Thalassemia

Intervention

Medical Chart Summary

Location

Pediatric Hematology Unit - Ha'Emek Medical Center
Afula
Israel
18101

Status

Recruiting

Source

HaEmek Medical Center, Israel

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:19:31-0400

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A disorder characterized by reduced synthesis of the beta chains of hemoglobin. There is retardation of hemoglobin A synthesis in the heterozygous form (thalassemia minor), which is asymptomatic, while in the homozygous form (thalassemia major, Cooley's anemia, Mediterranean anemia, erythroblastic anemia), which can result in severe complications and even death, hemoglobin A synthesis is absent.

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