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Added-Value of LM/SL Plus SPECT/CT in Gynecological Cancers

2014-08-27 03:19:31 | BioPortfolio

Summary

The purpose of this study is to assess the technical feasibility and the clinical added-value of SPECT/CT as a complement to LM/SL in patients with early stage of cervical cancer and vulvar cancer.

Description

1. To compare the diagnostic accuracy of LM/SL + SPECT/CT versus LM/SL

- Rate of SLNs detected pre-operatively and intra-operatively

- Anatomic precision of SLNs detected pre-operatively (versus surgery)

2. To determine the predictive value of LM/SL + SPECT/CT for assessing regional lymph node status

- Rate of SLNs histologically involved versus non-SLNs

- Rate of tumor-free SLNs versus non-SLNS

3. To assess the safety of LM/SL + SPECT/CT

- Patients' tolerability

- Duration of operating time for SPECT-CT guided sentinel lymphadenectomy

- Complications rate

Study Design

Allocation: Non-Randomized, Control: Active Control, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic

Conditions

Cervical Cancer

Intervention

SPECT/CT guided LM/SL

Location

Victoria Hospital
London
Ontario
Canada
N6A 5W9

Status

Recruiting

Source

Lawson Health Research Institute

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:19:31-0400

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Medical and Biotech [MESH] Definitions

Morphological abnormalities of the cervical EPITHELIUM, usually revealed in PAP SMEAR, which do not meet the criteria for squamous CERVICAL INTRAEPITHELIAL NEOPLASIA or SQUAMOUS CELL CARCINOMAS of the CERVIX . It may be a sign of infection with certain types of human papillomavirus (HPV).or sign of a benign (not cancer) growth, such as a cyst or polyp or, in menopausal women, of low hormone levels. More testing, such as HPV test, may be needed.

A network of nerve fibers originating in the upper four cervical spinal cord segments. The cervical plexus distributes cutaneous nerves to parts of the neck, shoulders, and back of the head, and motor fibers to muscles of the cervical spinal column, infrahyoid muscles, and the diaphragm.

A method of computed tomography that uses radionuclides which emit a single photon of a given energy. The camera is rotated 180 or 360 degrees around the patient to capture images at multiple positions along the arc. The computer is then used to reconstruct the transaxial, sagittal, and coronal images from the 3-dimensional distribution of radionuclides in the organ. The advantages of SPECT are that it can be used to observe biochemical and physiological processes as well as size and volume of the organ. The disadvantage is that, unlike positron-emission tomography where the positron-electron annihilation results in the emission of 2 photons at 180 degrees from each other, SPECT requires physical collimation to line up the photons, which results in the loss of many available photons and hence degrades the image.

A parameter usually used in PRENATAL ULTRASONOGRAPHY to measure the length of the uterine neck (CERVIX UTERI). Cervical length or its shortening is used to identify and prevent early cervical opening and PRETERM BIRTH.

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