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Thyroid Function in Late Preterm Infants

2014-08-27 03:19:32 | BioPortfolio

Summary

Transient hypothyroxinemia (TH) is a condition characterized by low levels of serum thyroxine (T4) and normal levels of thyroid stimulating hormone (TSH). TH in premature infants has been found to be related to severity of illness. T4 levels in very low birth weight infants born prematurely has been found to be inversely correlated to severity of illness. In very low birth weight infants, TH has been associated with poor outcomes. Little is known about thyroid function in late preterm infants.

Hypotheses:

1. Ill late preterm infants will have lower total T4 levels than healthy late preterm infants.

2. Total T4 and possibly TSH levels will be inversely correlated with short-term outcomes.

3. Late Preterm infants born by cesarean section will have lower T4 levels compared to those born by vaginal birth.

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Conditions

Transient Hypothyroxinemia

Location

Christiana Hospital
Newark
Delaware
United States
19718

Status

Recruiting

Source

Christiana Care Health Services

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:19:32-0400

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Medical and Biotech [MESH] Definitions

Brief reversible episodes of focal, nonconvulsive ischemic dysfunction of the brain having a duration of less than 24 hours, and usually less than one hour, caused by transient thrombotic or embolic blood vessel occlusion or stenosis. Events may be classified by arterial distribution, temporal pattern, or etiology (e.g., embolic vs. thrombotic). (From Adams et al., Principles of Neurology, 6th ed, pp814-6)

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A transient absence of spontaneous respiration.

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