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Evaluation of [18F] FEPPA and Positron Emission Tomography (PET) as a Marker of Inflammation in Subjects With Neurological Conditions

2014-08-27 03:19:37 | BioPortfolio

Summary

Ultimately a marker of microglial activation could be used for large-scale quantitative brain imaging trials in Alzheimer Disease (AD), Parkinson Disease (PD) or Multiple Sclerosis (MS), specifically to investigate the agent as an objective biomarker in treatments aimed at reducing inflammatory changes in these conditions. The significance of this work lies in applying state-of-art quantitative neuroimaging tools to develop a relevant biomarker in individuals with neurodegenerative diseases with the intention of using this efficiently in large clinical imaging trials.

Description

The adaptation of imaging agents like [18F]-FEPPA as a biomarker of microglial activation in neurodegenerative and neuroinflammatory diseases requires human validation studies. Expanding upon our previous work with B-amyloid ligands (123I-IMPY, 123I MNI-187) for AD and dopamine transporter ligands (123I B-CIT, Altropane) for PD, we desire to develop and characterize [18F]-FEPPA as a potential marker for microglial activation in association with neuronal damage that may be applicable to multiple neurodegenerative and inflammatory diseases.

Study Design

Allocation: Non-Randomized, Control: Active Control, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic

Conditions

Alzheimer Disease

Intervention

[18F]-FEPPA

Location

Instiute for Neurodegenerative Disorders
New Haven
Connecticut
United States
06510

Status

Recruiting

Source

Institute for Neurodegenerative Disorders

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:19:37-0400

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