Advertisement

Topics

Effects of Methylprednisolone After Total Hip Arthroplasty

2014-08-27 03:19:38 | BioPortfolio

Summary

The purpose of the study is to compare the effects of pre-operative methylprednisolone (125mg iv) versus placebo on postoperative outcome after hip arthroplasty.

The hypothesis is that pre-operative methylprednisolone (125mg iv) will reduce time to fulfill discharge criteria.

Description

In spite of being one of the last century's most successful surgical procedures in treatment of advanced osteoarthritis total hip arthroplasty is still associated with postoperative pain and delayed rehabilitation. We therefore decided to evaluate the effects of pre-operative methylprednisolone (125mg iv) versus placebo on postoperative outcome in a well defined fast-track setup after hip arthroplasty.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Supportive Care

Conditions

LOS

Intervention

Methylprednisolone

Location

Hvidovre University Hospital
Copenhagen
Hvidovre
Denmark
2650

Status

Recruiting

Source

Hvidovre University Hospital

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:19:38-0400

Clinical Trials [91 Associated Clinical Trials listed on BioPortfolio]

Local Steroid Injection vs Placebo in Carpal Tunnel Syndrome

Between 2008 and 2012 we performed a single-center randomized double-blind placebo-controlled trial to assess the efficacy of local injection of two different doses of methylprednisolone (...

A Comparison of Methotrexate Alone or Combined to Infliximab or to Pulse Methylprednisolone in Early Rheumatoid Arthritis: A Magnetic Resonance Imaging Study

The purpose of the study is to compare the effects of methotrexate (MTX) alone or in combination with intravenous (IV) methylprednisolone (MP) or infliximab (IFX) on MRI-detected synovitis...

Urinary Aquaporin 2 Excretion After Methylprednisolone in Fasting Healthy Humans

We wanted to test the hypotheses that methylprednisolone up regulates u-AQP-2 in fasting healthy humans

Administration of Methylprednisolone for Prevention of Ovarian Hyper Stimulation Syndrome

This study is a prospective randomized clinical controlled trial to assess the efficacy of the Methylprednisolone for preventing ovarian hyper stimulation syndrome in in vitro fertilizatio...

Study to Evaluate Intravenous and Oral Steroids for Multiple Sclerosis Attacks

This clinical trial compares the relative efficacy of treating acute exacerbations of relapsing forms of Multiple Sclerosis with equivalent doses of oral and intravenous (IV) methylprednis...

PubMed Articles [56 Associated PubMed Articles listed on BioPortfolio]

Effects of methylprednisolone on the duration of rocuronium-induced neuromuscular block: A randomized double-blind trial.

We aim to investigate whether intraoperative use of methylprednisolone could affect the duration of rocuronium-induced neuromuscular blockade.

GSH-PEGylated liposomal methylprednisolone in comparison to free methylprednisolone: slow release characteristics and prolonged lymphocyte depression in a first-in-human study.

Intravenous high-dose free methylprednisolone hemisuccinate (MP) is the primary treatment for an acute relapse in relapsing-remitting (RR) multiple sclerosis (MS). However, it is inconvenient and its ...

A randomized study of cyclosporine and methotrexate with or without methylprednisolone for the prevention of graft-versus-host disease: Improved long-term survival with triple prophylaxis.

In a previously published study, the authors randomized 108 adult patients with a malignant hematologic disorder undergoing allogeneic bone marrow transplantation from a human leukocyte antigen-identi...

Methimazole-induced liver injury overshadowed by methylprednisolone pulse therapy: Case report.

Treatment choices are limited, when deciding how to manage thyrotoxicosis and moderate to severe Graves ophthalmopathy (GO) with suspected optic nerve damage in patients with elevated liver transamina...

Intra-articular injection of methylprednisolone for reducing pain in knee osteoarthritis: A systematic review and meta-analysis.

To evaluate the efficacy and safety of intra-articular methylprednisolone for reducing pain in patients with knee osteoarthritis.

Medical and Biotech [MESH] Definitions

A water-soluble ester of METHYLPREDNISOLONE used for cardiac, allergic, and hypoxic emergencies.

A PREDNISOLONE derivative with similar anti-inflammatory action.

More From BioPortfolio on "Effects of Methylprednisolone After Total Hip Arthroplasty"

Advertisement
Quick Search
Advertisement
Advertisement

 

Relevant Topics

Arthroplasty
Arthroplasty is a surgical procedure to restore the integrity and function of a joint. A joint can be restored by resurfacing the bones. An artificial joint (called a prosthesis) may also be used. Various types of arthritis may affect the joints. Osteo...

Arthritis
Arthritis is by definition the inflammation of one or more joints, characterized by swelling, pain, warmth, redness and diminished range of joint movement (Oxford Medical Dictionary). There are many different types; Noninflammatory; Osteoarthritis, N...


Searches Linking to this Trial